ArticleBrain pathology (Zurich, Switzerland)2006
Human herpesvirus 6 and multiple sclerosis: a one-year follow-up study.
Article in Brain pathology (Zurich, Switzerland), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Childhood and Adolescent Environmental Risk Factors for Multiple Sclerosis: A Systematic Review With Meta-Analysis.European journal of neurology · 2025Pooled it
- Review
- Heightened Epstein-Barr virus immunity and potential cross-reactivities in multiple sclerosis.PLoS pathogens · 2024Article
- Herpesvirus Infections in KIR2DL2-Positive Multiple Sclerosis Patients: Mechanisms Triggering Autoimmunity.Microorganisms · 2022Article
- The Association of EBV and HHV-6 Viral Load with Different NK and CD8Cell journal · 2021Article
- Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation.Clinical microbiology reviews · 2020Review
- Epstein-Barr virus and multiple sclerosis: potential opportunities for immunotherapy.Clinical & translational immunology · 2014Review
- Classification of HHV-6A and HHV-6B as distinct viruses.Archives of virology · 2014Review
- Oligoclonal bands in multiple sclerosis reactive against two herpesviruses and association with magnetic resonance imaging findings.Multiple sclerosis (Houndmills, Basingstoke, England) · 2014Article
- Anti-human herpesvirus 6A/B IgG correlates with relapses and progression in multiple sclerosis.PloS one · 2014Article
- Article
- Prevalence of human herpesvirus U94/REP antibodies and DNA in Tunisian multiple sclerosis patients.Journal of neurovirology · 2013Article
- Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization.PLoS pathogens · 2013Article
- Viruses and multiple sclerosis.CNS & neurological disorders drug targets · 2012Review
- Identification of human herpesviruses 1 to 8 in Tunisian multiple sclerosis patients and healthy blood donors.Journal of neurovirology · 2012Article
- CD46 processing: a means of expression.Immunobiology · 2012Review
- CD46 plasticity and its inflammatory bias in multiple sclerosis.Archivum immunologiae et therapiae experimentalis · 2011Review
- Human herpesvirus 6 infection as a trigger of multiple sclerosis.Mayo Clinic proceedings · 2010Review
- Effect of (r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT-lipid-PFA on human herpesvirus-6B infected cells.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2009Article
- Detection of human herpesvirus-6 in cerebrospinal fluid of patients with encephalitis.Annals of neurology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study was undertaken in order to investigate the possible relation of HHV-6 and EBV in relapsing-remitting MS (RRMS). MATERIALS AND
methodsA one-year follow up study was performed analysing peripheral blood mononuclear cells and serum samples of 57 patients with RRMS and 57 healthy blood donors (HBD) by a quantitative real time PCR, to detect HHV-6 and EBV. Clinical data (starting age and EDSS increase) were collected.
resultsWe did not find any statistically significant difference for EBV between RRMS patients and HBD. Regarding HHV-6: i) There was a higher prevalence of HHV-6 in RRMS patients than in controls: 80.7% versus 29.8% respectively. ii) HHV-6 active replication seems to be related to exacerbations. iii) Only variant A was detected among RRMS patients with HHV-6 active replication. iv) Although some difference was found when we compared clinical data in RRMS patients with and without HHV-6 active replication, the results did not reach statistical significance.
conclusionsA higher HHV-6A frequency of active infection (reactivation or new infection) would lead to a more frequent exposure of HHV-6A antigens to the immune system of RRMS patients; this active replication of HHV-6A seems to be specifically related with the exacerbations in a subset of RRMS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.