ArticleVirchows Archiv : an international journal of pathology2006
Genetic similarities and differences between lobular in situ neoplasia (LN) and invasive lobular carcinoma of the breast.
Article in Virchows Archiv : an international journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 68 citations in OpenAlex.
- Lobular Breast Cancer: Histomorphology and Different Concepts of a Special Spectrum of Tumors.Cancers · 2021Review
- Genomic profiling of pleomorphic and florid lobular carcinoma in situ reveals highly recurrent ERBB2 and ERRB3 alterations.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships.Molecular oncology · 2016Article
- Molecular drivers of lobular carcinoma in situ.Breast cancer research : BCR · 2015Review
- Molecular analysis of pancreatic acinar cell cystadenomas: Evidence of a non-neoplastic nature.Oncology letters · 2014Article
- Beyond laser microdissection technology: follow the yellow brick road for cancer research.American journal of cancer research · 2014Review
- Analysis of gene alterations of mitochondrial DNA D-loop regions to determine breast cancer clonality.British journal of cancer · 2012Article
- Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions.Breast cancer research : BCR · 2012Article
- Cadherin-catenin complex dissociation in lobular neoplasia of the breast.Breast cancer research and treatment · 2012Article
- Relevance of PTEN loss in brain metastasis formation in breast cancer patients.Breast cancer research : BCR · 2012Article
- [Ductal and lobular preneoplasia: role in breast cancer development].Der Pathologe · 2011Article
- The molecular pathology of breast cancer progression.The Journal of pathology · 2011Review
- Nasal seromucinous hamartoma (microglandular adenosis of the nose): a morphological and molecular study of five cases.Virchows Archiv : an international journal of pathology · 2010Article
- Article
- Preinvasive breast cancer.Annual review of pathology · 2010Review
- Breast cancer precursors: lessons learned from molecular genetics.Journal of molecular medicine (Berlin, Germany) · 2009Article
- [Clonal association of flat epithelial atypia and tubular breast cancer].Der Pathologe · 2008Article
- A short guide to hereditary diffuse gastric cancer.Hereditary cancer in clinical practice · 2007Article
- Non-operative breast pathology: lobular neoplasia.Journal of clinical pathology · 2007Review
- Immunohistochemical expression of estrogen receptors alpha and beta in lobular neoplasia.Virchows Archiv : an international journal of pathology · 2007Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most controversial issues in breast pathology is whether lobular neoplasia (LN) is a risk factor or a precursor lesion of invasive lobular carcinoma (ILC). This is consequent to the fact that no conclusive data on the biology of LN exist. Molecular studies of LN and ILC are scanty, variable, and not consistent. Clonality of 12 cases of LN and ILC present simultaneously in the same block has been studied. Cells from both lesions were obtained by microdissection and were studied for mitochondrial DNA (mtDNA), D-loop sequencing, and neighbor-joining trees. Eight of the same cases were studied with comparative genomic hybridization (CGH) array to have additional data consistent with mtDNA. In all cases, loss of heterozygosity was studied for D16S496,locus 16q22.1 related to e-cadherin. It appears that no fewer than eight cases were genetically very similar (clonal) with mtDNA. Seven of these cases appeared also clonal with CGH array. It is concluded that in the present series, LN and ILC are genetically related lesions in the majority of cases and that LN might be the precursor of ILC.
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