SynthesisHuman genetics2006
Genome-wide meta-analysis for rheumatoid arthritis.
Synthesis in Human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Exploring the impact of SNPs rs2476601, rs2488457, and rs33996649 onFrontiers in medicine · 2025Article
- NLRP1, PTPN22 and PADI4 gene polymorphisms and rheumatoid arthritis in ACPA-positive Singaporean Chinese.Rheumatology international · 2017Article
- Antibodies against cyclic citrullinated peptides of IgG, IgA and IgM isotype and rheumatoid factor of IgM and IgA isotype are increased in unaffected members of multicase rheumatoid arthritis families from northern Sweden.Annals of the rheumatic diseases · 2012Article
- Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis.Genes and immunity · 2012Article
- Wnt signaling genes of murine chromosome 15 are involved in sex-affected pathways of inflammatory arthritis.Arthritis and rheumatism · 2012Article
- Non-MHC risk alleles in rheumatoid arthritis and in the syntenic chromosome regions of corresponding animal models.Clinical & developmental immunology · 2012Review
- Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis.Arthritis and rheumatism · 2011Article
- CIITA is not associated with risk of developing rheumatoid arthritis.Genes and immunity · 2011Article
- A candidate gene study of CLEC16A does not provide evidence of association with risk for anti-CCP-positive rheumatoid arthritis.Genes and immunity · 2010Article
- Use of supplementary phenotype to identify additional rheumatoid arthritis loci in a linkage analysis of 342 UK affected sibling pair families.BMC medical genetics · 2009Article
- TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.The New England journal of medicine · 2007Article
- STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.The New England journal of medicine · 2007Article
- Cia25 on rat chromosome 12 regulates severity of autoimmune arthritis induced with pristane and with collagen.Annals of the rheumatic diseases · 2007Article
- Linkage proof for PTPN22, a rheumatoid arthritis susceptibility gene and a human autoimmunity gene.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Novel approach for genome scan meta-analysis of rheumatoid arthritis: a kernel-based estimation procedure.BMC proceedings · 2007Article
- Identifying single-nucleotide polymorphisms responsible for the linkage signal of rheumatoid arthritis on chromosome 6 by joint modeling of linkage and association.BMC proceedings · 2007Article
- Combining multiple family-based association studies.BMC proceedings · 2007Article
- Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis.BMC proceedings · 2007Article
- One- and two-locus models for mapping rheumatoid arthritis-susceptibility genes on chromosome 6.BMC proceedings · 2007Article
- Combining linkage data sets for meta-analysis and mega-analysis: the GAW15 rheumatoid arthritis data set.BMC proceedings · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Meta-analysis is being increasingly used as a tool for integrating data from different studies of complex phenotypes, because the power of any one study to identify causal loci is limited. We applied a novel meta-analytical approach (Loesgen et al. in Genet Epidemiol 21(Suppl 1):S142-S147, 2001) in compiling results from four studies of rheumatoid arthritis in Caucasians including two studies from NARAC (Jawaheer et al. in Am J Hum Genet 68:927-936, 2001; Jawaheer et al. in Arthritis Rheum 48:906-916, 2003), one study from the UK (MacKay et al. in Arthritis Rheum 46:632-639, 2001) and one from France (Cornelis et al. in Proc Natl Acad Sci USA 95:10746-10750, 1998). For each study, we obtained NPL scores by performing interval mapping (2 cM intervals) using GeneHunter2 (Kruglyak et al. in Am J Hum Genet 58:1347-1363, 1996; Markianos et al. in Am J Hum Genet 68:963-977, 2001). The marker maps differed among the three consortium groups, therefore, the marker maps were aligned after the interval mapping was completed and the NPL scores that were within 1 cM of each other were combined using the method of Loesgen et al. (Genet Epidemiol 21(Suppl 1):S142-S147, 2001) by calculating the weighted average of the NPL score. This approach avoids some problems in analysis encountered by using GeneHunter2 when some markers in the sample are not genotyped. This procedure provided marginal evidence (P<0.05) of linkage on chromosome 1, 2, 5 and 18, strong evidence (P<0.01) on chromosomes 8 and 16, and overwhelming evidence in the HLA region of chromosome 6.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.