ArticleHistochemistry and cell biology2006
Expression of P2X receptors on immune cells in the rat liver during postnatal development.
Article in Histochemistry and cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Association of rapamycin treatment with the modulation of purine metabolism, reduced microglial inflammatory responses, improved mitochondrial energy metabolism, and alleviation of fatigue symptoms in ME/CFS subjects: pilot findings from phase-II observational study.Journal of translational medicine · 2026Trial
- Purinergic Receptors in Dendritic Cells.Journal of inflammation research · 2025Review
- Purinergic Signaling in Non-Parenchymal Liver Cells.International journal of molecular sciences · 2024Review
- Purinergic regulation of the immune system.Nature reviews. Immunology · 2016Review
- Purinergic signalling in the liver in health and disease.Purinergic signalling · 2014Review
- P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- Role of purinergic P2X receptors in the control of liver homeostasis.Wiley interdisciplinary reviews. Membrane transport and signaling · 2012Article
- Expression and functional characterization of P2X receptors in mouse alveolar macrophages.Pflugers Archiv : European journal of physiology · 2011Article
- ATP release after partial hepatectomy regulates liver regeneration in the rat.Journal of hepatology · 2010Article
- Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia.Journal of neuroinflammation · 2009Article
- P2X receptors are differentially expressed on vasopressin- and oxytocin-containing neurons in the supraoptic and paraventricular nuclei of rat hypothalamus.Histochemistry and cell biology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single and double-labeling immunofluorescence and RT-PCR expression of P2X receptor proteins and mRNAs were used in a study of the liver of postnatal rats. OX62 and ED1 were used as markers for dendritic and macrophage (Kupffer) cells respectively. The results showed that the P2X6 receptor subunit was up-regulated by 15-fold on hepatic sinusoid cells during postnatal days P1 to P60. Subpopulations of Kupffer cells co-expressed P2X4 and P2X6 receptor subunits and dendritic cells co-expressed P2X4 and P2X7 receptor subunits. Lipopolysaccharide (endotoxin) injected into the peritoneal cavity led to increased expression of the P2X6 receptor on Kupffer cells, suggesting that the P2X6 receptor subunit may be up-regulated by endotoxin. This study presents the first evidence that P2X receptors are widely distributed in the rat liver immune system and that activation of Kupffer and dendritic cells in the rat liver might be regulated by extracellular ATP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.