ArticleJournal of virology2006
Prion infection of oral and nasal mucosa.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Longitudinal detection of prion shedding in nasal secretions of CWD-infected white-tailed deer.The Journal of general virology · 2023Article
- Article
- Review
- Detection of Pathognomonic Biomarker PrPBiomolecules · 2020Review
- Implications of peptide assemblies in amyloid diseases.Chemical Society reviews · 2017Review
- Infectious Prions in the Pregnancy Microenvironment of Chronic Wasting Disease-Infected Reeves' Muntjac Deer.Journal of virology · 2017Article
- Article
- Seeded Amplification of Chronic Wasting Disease Prions in Nasal Brushings and Recto-anal Mucosa-Associated Lymphoid Tissues from Elk by Real-Time Quaking-Induced Conversion.Journal of clinical microbiology · 2016Article
- Lesion of the olfactory epithelium accelerates prion neuroinvasion and disease onset when prion replication is restricted to neurons.PloS one · 2015Article
- Mineral licks: motivational factors for visitation and accompanying disease risk at communal use sites of elk and deer.Environmental geochemistry and health · 2014Article
- Axonal and transynaptic spread of prions.Journal of virology · 2014Article
- Mucosal transmission and pathogenesis of chronic wasting disease in ferrets.The Journal of general virology · 2013Article
- Accelerated shedding of prions following damage to the olfactory epithelium.Journal of virology · 2012Article
- Conserved properties of human and bovine prion strains on transmission to guinea pigs.Laboratory investigation; a journal of technical methods and pathology · 2011Article
- Detection of chronic wasting disease prions in salivary, urinary, and intestinal tissues of deer: potential mechanisms of prion shedding and transmission.Journal of virology · 2011Article
- Aerosols transmit prions to immunocompetent and immunodeficient mice.PLoS pathogens · 2011Article
- Transmission of chronic wasting disease identifies a prion strain causing cachexia and heart infection in hamsters.PloS one · 2011Article
- Aerosol and nasal transmission of chronic wasting disease in cervidized mice.The Journal of general virology · 2010Article
- Pathogenesis of chronic wasting disease in cervidized transgenic mice.The American journal of pathology · 2010Article
- Prion shedding from olfactory neurons into nasal secretions.PLoS pathogens · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Centrifugal spread of the prion agent to peripheral tissues is postulated to occur by axonal transport along nerve fibers. This study investigated the distribution of the pathological isoform of the protein (PrP(Sc)) in the tongues and nasal cavities of hamsters following intracerebral inoculation of the HY strain of the transmissible mink encephalopathy (TME) agent. We report that PrP(Sc) deposition was found in the lamina propria, taste buds, and stratified squamous epithelium of fungiform papillae in the tongue, as well as in skeletal muscle cells. Using laser scanning confocal microscopy, PrP(Sc) was localized to nerve fibers in each of these structures in the tongue, neuroepithelial taste cells of the taste bud, and, possibly, epithelial cells. This PrP(Sc) distribution was consistent with a spread of HY TME agent along both somatosensory and gustatory cranial nerves to the tongue and suggests subsequent synaptic spread to taste cells and epithelial cells via peripheral synapses. In the nasal cavity, PrP(Sc) accumulation was found in the olfactory and vomeronasal epithelium, where its location was consistent with a distribution in cell bodies and apical dendrites of the sensory neurons. Prion spread to these sites is consistent with transport via the olfactory nerve fibers that descend from the olfactory bulb. Our data suggest that epithelial cells, neuroepithelial taste cells, or olfactory sensory neurons at chemosensory mucosal surfaces, which undergo normal turnover, infected with the prion agent could be shed and play a role in the horizontal transmission of animal prion diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.