ArticleJournal of virology2006
Crystal structure of the simian virus 40 large T-antigen origin-binding domain.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A model for polyomavirus helicase activity derived in part from the AlphaFold2 structure of SV40 T-antigen.Journal of virology · 2024Article
- SV40 T-antigen uses a DNA shearing mechanism to initiate origin unwinding.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains.PLoS pathogens · 2016Article
- Identification of Two Novel Members of the Tentative Genus Wukipolyomavirus in Wild Rodents.PloS one · 2015Article
- Insights into the initiation of JC virus DNA replication derived from the crystal structure of the T-antigen origin binding domain.PLoS pathogens · 2014Article
- Analysis of the costructure of the simian virus 40 T-antigen origin binding domain with site I reveals a correlation between GAGGC spacing and spiral assembly.Journal of virology · 2013Article
- Modeling of the SV40 DNA Replication Machine.Genes · 2012Article
- A common feature from different subunits of a homomeric AAA+ protein contacts three spatially distinct transcription elements.Nucleic acids research · 2012Article
- A wolf in sheep's clothing: SV40 co-opts host genome maintenance proteins to replicate viral DNA.PLoS pathogens · 2012Review
- Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin.Journal of molecular biology · 2011Article
- Structure-based design of a disulfide-linked oligomeric form of the simian virus 40 (SV40) large T antigen DNA-binding domain.Acta crystallographica. Section D, Biological crystallography · 2011Article
- Structure-based analysis of the interaction between the simian virus 40 T-antigen origin binding domain and single-stranded DNA.Journal of virology · 2011Article
- Origin DNA melting and unwinding in DNA replication.Current opinion in structural biology · 2010Review
- Conformational rearrangements of SV40 large T antigen during early replication events.Journal of molecular biology · 2010Article
- The minimum replication origin of merkel cell polyomavirus has a unique large T-antigen loading architecture and requires small T-antigen expression for optimal replication.Journal of virology · 2009Article
- The Mcm complex: unwinding the mechanism of a replicative helicase.Microbiology and molecular biology reviews : MMBR · 2009Review
- DNA structure modulates the oligomerization properties of the AAV initiator protein Rep68.PLoS pathogens · 2009Article
- Simian virus 40 large T antigen can specifically unwind the central palindrome at the origin of DNA replication.Journal of virology · 2009Article
- SV40 DNA replication: from the A gene to a nanomachine.Virology · 2009Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The origins of replication of DNA tumor viruses have a highly conserved feature, namely, multiple binding sites for their respective initiator proteins arranged as inverted repeats. In the 1.45-angstroms crystal structure of the simian virus 40 large T-antigen (T-ag) origin-binding domain (obd) reported herein, T-ag obd monomers form a left-handed spiral with an inner channel of 30 angstroms having six monomers per turn. The inner surface of the spiral is positively charged and includes residues known to bind DNA. Residues implicated in hexamerization of full-length T-ag are located at the interface between adjacent T-ag obd monomers. These data provide a high-resolution model of the hexamer of origin-binding domains observed in electron microscopy studies and allow the obd's to be oriented relative to the hexamer of T-ag helicase domains to which they are connected.
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