ArticleJournal of virology2006
Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Article
- Removal of a small C-terminal region of JCV and SV40 large T antigens has differential effects on transformation.Virology · 2014Article
- Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.Journal of virology · 2013Article
- Prothymosin α overexpression contributes to the development of pulmonary emphysema.Nature communications · 2013Article
- Article
- Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a murine model of Cockayne syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- JC virus small T antigen binds phosphatase PP2A and Rb family proteins and is required for efficient viral DNA replication activity.PloS one · 2010Article
- Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity.The Journal of biological chemistry · 2010Article
- Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation.Journal of virology · 2009Article
- A structure-guided mutational analysis of simian virus 40 large T antigen: identification of surface residues required for viral replication and transformation.Journal of virology · 2009Article
- Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways.Molecular biology of the cell · 2009Article
- Identification of new p53 acetylation sites in COS-1 cells.Molecular & cellular proteomics : MCP · 2009Article
- Adenovirus transforming protein E1A induces c-Myc in quiescent cells by a novel mechanism.Journal of virology · 2009Article
- Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.Journal of virology · 2009Article
- Simian virus 40 large T overcomes p300 repression of c-Myc.Virology · 2008Article
- The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53.PloS one · 2008Article
- A genomic screen for activators of the antioxidant response element.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein.Journal of virology · 2007Article
- Antagonistic pleiotropy and p53.Mechanisms of ageing and developmentReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The primary transforming functions of simian virus 40 large T antigen (SV40 LT) are conferred primarily through the binding and inactivation of p53 and the retinoblastoma family members. Normal p53 function requires an association with the CREB binding protein (CBP)/p300 coactivators, and a ternary complex containing SV40 LT, p53, and CBP/p300 has been identified previously. In this report, we have evaluated a secondary function of p53 bound to the SV40 LT complex in mediating the binding of human CBP/p300. We demonstrate that p53 associated with SV40 LT was posttranslationally modified in a manner consistent with the binding of CBP/p300. Furthermore, expression of SV40 LT induced the proportion of p53 phosphorylated on S15. An essential function for p53 in bridging the interaction between SV40 LT and CBP/p300 was identified through the reconstitution of the SV40 LT-CBP/p300 complex upon p53 reexpression in p53-null cells. In addition, the SV40 LT-CBP/p300 complex was disrupted through RNA interference-mediated depletion of endogenous p53. We also demonstrate that SV40 LT was acetylated in a p300- and p53-dependent manner, at least in part through the CH3 domain of p300. Therefore, the binding of p53 serves to modify SV40 LT by targeting CBP and p300 binding to direct the acetylation of SV40 LT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.