ArticleAnnals of the rheumatic diseases2006
Morphological and quantitative assessment of mast cells in rheumatoid arthritis associated non-specific interstitial pneumonia and usual interstitial pneumonia.
Article in Annals of the rheumatic diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 13 citations in OpenAlex.
- Inmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo.Journal of clinical and experimental dentistry · 2015Article
- Image analysis tools for evaluation of microscopic views of immunohistochemically stained specimen in medical research-a review.Journal of medical systems · 2012Review
- Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe role of mast cells in extra-articular manifestations of rheumatoid arthritis (RA) has not been studied so far.
objectiveTo characterise and quantify mast cells in RA associated interstitial pneumonia (IP) by an immunohistological study.
methodsLung biopsy specimens from 15 patients with RA associated IP, 12 patients with idiopathic IP, and 5 control patients were stained with antibodies directed against tryptase (mast cell marker). Morphological characterisation of stained specimens was carried out and staining was quantified by computer assisted image analysis.
resultsTryptase staining showed the marked presence of mast cells in idiopathic IP and in RA associated IP. A significant difference in stained tissue area was found between RA associated IP (2.6%, IQR 2.0-3.2%, p = 0.015) and idiopathic IP (3.1%, IQR 1.8-3.7%, p = 0.003) compared with control tissue specimens (1.0%, IQR 0.7-1.5%). The extent of mast cell infiltration correlated well and inversely with pulmonary function variables.
conclusionsMast cell infiltrates are present in RA associated IP and idiopathic IP. The observed correlation of pulmonary function and mast cell numbers would be consistent with the proposed role of mast cell mediators in the promotion of fibrogenesis. The findings provide a rationale for studying functional aspects of mast cell involvement in the pathogenesis of RA associated lung disease.
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