ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Associative memory stored by functional novel pathway rather than modifications of preexisting neuronal pathways.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- The role of non-coding RNAs in the formation of long-term associative memory after single-trial learning inFrontiers in behavioral neuroscience · 2022Review
- Involvement of insulin-like peptide in long-term synaptic plasticity and long-term memory of the pond snail Lymnaea stagnalis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Susceptibility of memory consolidation during lapses in recall.Nature communications · 2013Article
- Distributed network organization underlying feeding behavior in the mollusk Lymnaea.Neural systems & circuits · 2012Article
- Role of tonic inhibition in associative reward conditioning in lymnaea.Frontiers in behavioral neuroscience · 2010Article
- Olfactory experience modifies the effect of odour on feeding behaviour in a goal-related manner.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2008Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Associative conditioning involves changes in the processing pathways activated by sensory information to link the conditioned stimulus (CS) to the conditioned behavior. Thus, conditioning can recruit neuronal elements to form new pathways for the processing of the CS and/or can change the strength of existing pathways. Using a behavioral and systems level electrophysiological approach on a tractable invertebrate circuit generating feeding in the mollusk Lymnaea stagnalis, we identified three independent pathways for the processing of the CS amyl acetate used in appetitive conditioning. Two of these pathways, one suppressing and the other stimulating feeding, mediate responses to the CS in naive animals. The effects of these two pathways on feeding behavior are unaltered by conditioning. In contrast, the CS response of a third stimulatory pathway is significantly enhanced after conditioning, becoming an important contributor to the overall CS response. This is unusual because, in most of the previous examples in which naive animals already respond to the CS, memory formation results from changes in the strength of pathways that mediate the existing response. Here, we show that, in the molluscan feeding system, both modified and unmodified pathways are activated in parallel by the CS after conditioning, and it is their integration that results in the conditioned response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.