ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Persistent responses to brief stimuli: feedback excitation among brainstem neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- State-dependent signal flow hierarchy in the human cerebral cortex.Nature neuroscience · 2026Article
- The dynamics of stimulus selection in the nucleus isthmi pars magnocellularis of avian midbrain network.Scientific reports · 2025Article
- Mechanisms Underlying the Recruitment of Inhibitory Interneurons in Fictive Swimming in DevelopingThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Layer 6A Pyramidal Cell Subtypes Form Synaptic Microcircuits with Distinct Functional and Structural Properties.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- An early midbrain sensorimotor pathway is involved in the timely initiation and direction of swimming in the hatchlingFrontiers in neural circuits · 2022Article
- Modeling Post-Scratching Locomotion with Two Rhythm Generators and a Shared Pattern Formation.Biology · 2021Article
- Corollary discharge promotes a sustained motor state in a neural circuit for navigation.eLife · 2021Article
- The decision to move: response times, neuronal circuits and sensory memory in a simple vertebrate.Proceedings. Biological sciences · 2019Review
- Stimulation of Single, Possible CHX10 Hindbrain Neurons Turns Swimming On and Off in YoungFrontiers in cellular neuroscience · 2019Article
- Article
- Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons.Current biology : CB · 2018Article
- A simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response times.The Journal of physiology · 2018Article
- Bifurcations of Limit Cycles in a Reduced Model of the Xenopus Tadpole Central Pattern Generator.Journal of mathematical neuroscience · 2018Article
- Article
- Developmental changes in spinal neuronal properties, motor network configuration, and neuromodulation at free-swimming stages of Xenopus tadpoles.Journal of neurophysiology · 2018Article
- Zebrafish transgenic constructs label specific neurons in Xenopus laevis spinal cord and identify frog V0v spinal neurons.Developmental neurobiology · 2017Article
- The modulation of two motor behaviors by persistent sodium currents inJournal of neurophysiology · 2017Article
- Mechanisms underlying the endogenous dopaminergic inhibition of spinal locomotor circuit function in Xenopus tadpoles.Scientific reports · 2016Article
- Decoding the organization of spinal circuits that control locomotion.Nature reviews. Neuroscience · 2016Review
- Modelling Feedback Excitation, Pacemaker Properties and Sensory Switching of Electrically Coupled Brainstem Neurons Controlling Rhythmic Activity.PLoS computational biology · 2016Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
The ability of brief stimuli to trigger prolonged neuronal activity is a fundamental requirement in nervous systems, common to motor responses and short-term memory. Bistable membrane properties and network feedback excitation have both been proposed as suitable mechanisms to sustain such persistent responses. There is now good experimental evidence for membrane bistability. In contrast, the long-standing hypotheses based on positive feedback excitation have yet to be supported by direct evidence for mutual excitatory connections between appropriate neurons. In young frog tadpoles (Xenopus), we show that a small region of caudal hindbrain and rostral spinal cord is sufficient to generate prolonged swimming in response to a brief stimulus. We used paired whole-cell patch recordings to identify hindbrain neurons in this region that actively excite spinal neurons to drive sustained swimming. We show directly that some of these hindbrain neurons make reciprocal excitatory connections with each other. We use a population model of the hindbrain network to illustrate how feedback excitation can provide a robust mechanism to generate persistent responses. Our recordings provide direct evidence for feedback excitation among neurons within a network that drives a prolonged response. Its presence in a lower brain region early in development suggests that it is a basic feature of neuronal network design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.