ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Requirement of Akt to mediate long-term synaptic depression in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 39 citations in OpenAlex.
- Presynaptic quantal size enhancement counteracts post-tetanic release depression.The Journal of physiology · 2025Article
- Gene model for the ortholog ofbioRxiv : the preprint server for biology · 2025Article
- Alterations of RNA-binding proteinFrontiers in molecular neuroscience · 2022Article
- Drosophila eugracilis - Akt.microPublication biology · 2022Article
- Aedes aegypti miRNA-33 modulates permethrin induced toxicity by regulating VGSC transcripts.Scientific reports · 2021Article
- Synaptic depression induced by postsynaptic cAMP production in the Drosophila mushroom body calyx.The Journal of physiology · 2018Article
- Machine Learning Analysis IdentifiesG3 (Bethesda, Md.) · 2017Article
- Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells.ACS chemical biology · 2017Article
- Myostatin-like proteins regulate synaptic function and neuronal morphology.Development (Cambridge, England) · 2017Article
- Article
- Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia.Frontiers in synaptic neuroscience · 2014Review
- Akt regulates glutamate receptor trafficking and postsynaptic membrane elaboration at the Drosophila neuromuscular junction.Developmental neurobiology · 2013Article
- AKT/GSK3 signaling pathway and schizophrenia.Frontiers in molecular neuroscience · 2012Article
- PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Two forms of long-term depression in a polysynaptic pathway in the leech CNS: one NMDA receptor-dependent and the other cannabinoid-dependent.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2009Article
- Regional Health and Function in the hippocampus: Evolutionary compromises for a critical brain region.Bioscience hypotheses · 2009Article
- Distinctive roles of different beta-amyloid 42 aggregates in modulation of synaptic functions.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Notch signaling is required for activity-dependent synaptic plasticity at the Drosophila neuromuscular junction.Journal of neurogenetics · 2009Article
- Identification and investigation of Drosophila postsynaptic density homologs.Bioinformatics and biology insights · 2008Article
- PAR-1 kinase phosphorylates Dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction.Neuron · 2007Article
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2 authors at 1 institution in 1 country.
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Abstract
Drosophila larval neuromuscular junction (NMJ) is a well established preparation enabling quantitative analyses of synaptic physiology at identifiable synapses. Here, we report the first characterization of synaptic long-term depression (LTD) at the Drosophila NMJ. LTD can be reliably induced by specific patterns of tetanic stimulation, and the level of LTD depends on both stimulus frequency and Ca2+ concentration. We provide evidence that LTD is likely a result of presynaptic changes. Through screening of targeted mutants with defects in memory or signal transduction pathways, we found that LTD is strongly reduced in the akt mutants. This defect can be rescued by acutely induced expression of the normal akt transgene, suggesting that altered LTD is not attributable to developmental abnormalities and that Akt is critical for the induction of LTD. Our study also indicates that the molecular mechanisms of LTD are distinct from that of short-term synaptic plasticity, because akt mutants showed normal short-term facilitation and posttetanic potentiation, whereas LTD was unaffected in mutants that exhibit defective short-term synaptic plasticity, such as dunce and rutabaga. The characterization of LTD allows genetic analysis of the molecular mechanisms of long-term synaptic plasticity in Drosophila and provides an additional assay for studying functions of genes pertaining to synaptic and behavioral plasticity.
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