ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Controlling the gain of rod-mediated signals in the Mammalian retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers.
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Who cites it
134 citing papers in PubMed, 189 citations in OpenAlex.
- Rod + cone signal interference impairs mesopic motion discriminability in a model circuit.Journal of vision · 2026Article
- Retinal Cx36 gap junctions in the inner and outer plexiform layers differentially control visual thresholds.iScience · 2026Article
- Junctional conductance of retinal AII amacrine cell electrical synapses is decreased by NMDA receptors.The Journal of physiology · 2026Article
- Decoding the roles of bipolar, amacrine, and horizontal cells.Handbook of clinical neurology · 2026Review
- Retinal Origins of Circadian Photoregulation's Specialized Dynamic Range and Temporal Integration.bioRxiv : the preprint server for biology · 2025Article
- A mechanism for pathological oscillations in mouse retinal ganglion cells in a model of night blindness.The Journal of general physiology · 2025Article
- The mysterious middlemen making your vision pop: understanding the function of amacrine cells.The Journal of physiology · 2025Review
- Luminance invariant encoding in mouse primary visual cortex.Cell reports · 2025Article
- Signal Detection Theoretic Estimates of the Murine Absolute Visual Threshold Are Independent of Decision Bias.eNeuro · 2024Article
- A pupillary contrast response in mice and humans: Neural mechanisms and visual functions.Neuron · 2024Article
- Biophysical neural adaptation mechanisms enable artificial neural networks to capture dynamic retinal computation.Nature communications · 2024Article
- Retinal bipolar cells borrow excitability from electrically coupled inhibitory interneurons to amplify excitatory synaptic transmission.bioRxiv : the preprint server for biology · 2024Article
- Functionally Distinct Circuits Are Linked by Heterocellular Electrical Synapses in the Thalamic Reticular Nucleus.eNeuro · 2024Article
- Multiple rod layers increase the speed and sensitivity of vision in nocturnal reef fishes.Proceedings. Biological sciences · 2023Article
- Regional variation in the organization and connectivity of the first synapse in the primate night vision pathway.iScience · 2023Article
- Light Adaptation of Retinal Rod Bipolar Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Nonspiking Interneurons in theeNeuro · 2023Article
- Characterization of scotopic and mesopic rod signaling pathways in dogs using the On-Off electroretinogram.BMC veterinary research · 2022Article
- Vision: Life on the dark side.Current biology : CB · 2022Article
- Use of extended protocols with nonstandard stimuli to characterize rod and cone contributions to the canine electroretinogram.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Effective sensory processing requires matching the gain of neural responses to the range of signals encountered. For rod vision, gain controls operate at light levels at which photons arrive rarely at individual rods, light levels too low to cause adaptation in rod phototransduction. Under these conditions, adaptation within a conserved pathway in mammalian retina maintains sensitivity as light levels change. To relate retinal signals to behavioral work on detection at low light levels, we measured how background light affects the gain and noise of primate ganglion cells. To determine where and how gain is controlled, we tracked rod-mediated signals across the mouse retina. These experiments led to three main conclusions: (1) the primary site of adaptation at low light levels is the synapse between rod bipolar and AII amacrine cells; (2) cellular noise after the gain control is nearly independent of background intensity; and (3) at low backgrounds, noise in the circuitry, rather than rod noise or fluctuations in arriving photons, limits ganglion cell sensitivity. This work provides physiological insights into the rich history of experiments characterizing how rod vision avoids saturation as light levels increase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.