ArticleAJNR. American journal of neuroradiology2006
Intra-arterial reteplase compared to urokinase for thrombolytic recanalization in acute ischemic stroke.
Article in AJNR. American journal of neuroradiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Thrombolysis for acute ischaemic stroke: development and update.Brain communications · 2025Review
- Non-Surgical Bleeding and Transurethral Resection of the Prostate (TURP) Syndrome after TURP Surgery: A Case Report and Literature Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Article
- An in vitro comparative study on clot lysis efficiency of urokinase and reteplase with the synergy of ultrasound needle.Heliyon · 2024Article
- Response Surface Methodology to Optimize the Expression Efficiency of Recombinant Reteplase.Iranian journal of biotechnology · 2023Article
- MicroRNA-144 promotes remote limb ischemic preconditioning-mediated neuroprotection against ischemic stroke via PTEN/Akt pathway.Acta neurologica Belgica · 2021Article
- Angiographic and Clinical Factors Related with Good Functional Outcome after Mechanical Thrombectomy in Acute Cerebral Artery Occlusion.Journal of Korean Neurosurgical Society · 2015Article
- Endovascular treatment for acute ischemic stroke patients: implications and interpretation of IMS III, MR RESCUE, and SYNTHESIS EXPANSION trials: A report from the Working Group of International Congress of Interventional Neurology.Journal of vascular and interventional neurology · 2014Article
- What is meant by "TICI"?AJNR. American journal of neuroradiology · 2013Review
- Intravenous thrombolytics for ischemic stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011Review
- Intra-arterial versus intra-venous thrombolysis within and after the first 3 hours of stroke onset.Archives of medical science : AMS · 2010Article
- Multimodal therapy for patients with acute ischemic stroke : outcomes and related prognostic factors.Journal of Korean Neurosurgical Society · 2009Article
- Vertebrobasilar recanalization after 12 h of onset using balloon expandable stent and thrombolysis.Emergency radiology · 2008Article
- Tissue-type plasminogen activator as a therapeutic target in stroke.Expert opinion on therapeutic targets · 2008Review
- Recent advances in intra-arterial thrombolysis.Annals of Indian Academy of Neurology · 2008Review
- Novel thrombolytic drugs: will they make a difference in the treatment of ischaemic stroke?CNS drugs · 2008Review
- TIMI, TIBI, TICI: I came, I saw, I got confused.AJNR. American journal of neuroradiology · 2007Review
- Safety of high doses of urokinase and reteplase for acute ischemic stroke.AJNR. American journal of neuroradiologyArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeReteplase (RP) and urokinase (UK) are being used "off-label" to treat acute ischemic stroke. The safety and efficacy of intra-arterial RP or UK in the treatment of acute ischemic stroke, however, has yet to be proved. We aim to evaluate the safety and efficacy of RP compared with UK in acute ischemic stroke patients with large vessel occlusion.
methodsRetrospective analysis was conducted of cases from a prospectively collected stroke data base on consecutive acute ischemic stroke patients with large vessel occlusion by digital subtraction angiography treated with intra-arterial RP or UK. Thrombolytic dosage, recanalization rate, intracerebral hemorrhage (ICH), mortality, and outcome were determined.
resultsThirty-three patients received RP and 22 received UK (mean doses, 2.5 +/- 1.4 mg and 690,000 +/- 562,000 U, respectively). Vascular occlusions included 9 basilar arteries (BAs), 7 internal carotid arteries (ICAs), and 17 middle cerebral arteries (MCAs) with RP and 9 BAs, 4 ICAs, and 9 MCAs with UK. Median baseline National Institutes of Health Stroke Scales were as follows: 16 (range, 5-25; 81% > or = 10) with RP and 17 (range, 6-38; 85% > or =10) with UK. Mean time from symptom onset to thrombolytic initiation: 333 +/- 230 minutes with RP and 343 +/- 169 minutes with UK. Recanalization rates were as follows: 82% with RP and 64% with UK (P = .13). Symptomatic ICH rates were as follows: 12% with RP and 4.5% with UK (P = .50). The mortality rate was 24% with RP and 27% with UK (P = .8).
conclusionAlthough limited in statistical power, our study suggests that, although IA thrombolysis with RP shows a trend for higher recanalization rates and hemorrhage rates, IA thrombolysis with RP is not significantly different in recanalization, outcome, mortality, and ICH compared with that of UK or rates reported with IA pro-UK.
Indexed as
Identifiers
16611762PMC8133993W1768377191What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.