ReviewAJNR. American journal of neuroradiology2006
Imaging-guided acute ischemic stroke therapy: From "time is brain" to "physiology is brain".
Review in AJNR. American journal of neuroradiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Application of beta regression to analyze ischemic stroke volume in NINDS rt-PA clinical trials.Neuroepidemiology · 2011Trial
- Multimodal CT imaging characteristics may predict post-reperfusion infarct volume in wake-up stroke patients.Quantitative imaging in medicine and surgery · 2023Article
- Role of uroguanylin's signalling pathway in the development of ischaemic stroke.The European journal of neuroscience · 2022Article
- Early EEG Alterations Correlate with CTP Hypoperfused Volumes and Neurological Deficit: A Wireless EEG Study in Hyper-Acute Ischemic Stroke.Annals of biomedical engineering · 2021Article
- CT perfusion in hyper-acute ischemic stroke: the acid test for COVID-19 fear.Neuroradiology · 2021Observational
- Rapid Intravenous Glyceryl Trinitrate in Ischemic Damage (RIGID) After Stroke: Rationale, Design and Protocol for a Prospective Randomized Controlled Trial.Frontiers in neurology · 2021Article
- Wireless Resonant Circuits Printed Using Aerosol Jet Deposition for MRI Catheter Tracking.IEEE transactions on bio-medical engineering · 2020Article
- Wake-up stroke and CT perfusion: effectiveness and safety of reperfusion therapy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Precision Medicine for Ischemic Stroke, Let Us Move Beyond Time Is Brain.Translational stroke research · 2018Article
- Pipeline for Analyzing Lesions After Stroke (PALS).Frontiers in neuroinformatics · 2018Article
- Interventional magnetic resonance imaging guided carotid embolectomy using a novel resonant marker catheter: demonstration of preclinical feasibility.Biomedical microdevices · 2017Article
- Prediction of infarction volume and infarction growth rate in acute ischemic stroke.Scientific reports · 2017Article
- Perfusion CT in acute stroke: effectiveness of automatically-generated colour maps.The British journal of radiology · 2017Article
- Dexmedetomidine alleviates cerebral ischemia-induced short-term memory impairment by inhibiting the expression of apoptosis-related molecules in the hippocampus of gerbils.Experimental and therapeutic medicine · 2017Article
- Imaging of Ischemic Stroke.Continuum (Minneapolis, Minn.) · 2016Review
- The Role of the Neuroprotective Factor Npas4 in Cerebral Ischemia.International journal of molecular sciences · 2015Review
- Computed tomography perfusion-based thrombolysis in wake-up stroke.Internal and emergency medicine · 2015Article
- TIME OF PRESENTATION OF STROKE PATIENTS FOR CT IMAGING IN A NIGERIAN TERTIARY HOSPITAL.Annals of Ibadan postgraduate medicine · 2015Article
- Involvement of bradykinin in brain edema development after ischemic stroke.Pflugers Archiv : European journal of physiology · 2015Review
- Role of EPI-FLAIR in patients with acute stroke: a comparative analysis with FLAIR.AJNR. American journal of neuroradiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The number of potential patients who are actually treated for acute ischemic stroke is disappointingly low, and effective treatments are making a minor impact on this major public health problem. Imaging is not regularly used to identify the ischemic penumbra, a key concept in stroke physiology, though it is capable of doing so in a clinically relevant manner. Evidence is accumulating that identification of the ischemic penumbra and making treatment decisions on the basis of its presence provide substantial benefit to patient outcomes. Moreover, the same studies suggest that an unexpectedly large proportion of patients are suitable for therapy well past the traditional time windows because of the existence of a substantial ischemic penumbra. Modern MR imaging and CT systems, now widely available, are capable of answering the most relevant physiologic questions in acute ischemic stroke. This capability presents new opportunities and responsibilities to neuroradiologists to make appropriate imaging readily available and to have the imaging data rapidly processed and interpreted. In this article, acute ischemic stroke therapy, including the role of imaging in current medical practice, is reviewed, and an evidence-based alternative to contemporary acute ischemic stroke therapy is suggested.
Indexed as
Identifiers
16611754PMC8133997What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.