ArticleMolecular biology of the cell2006
The rab exchange factor Sec2p reversibly associates with the exocyst.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 79 citations in OpenAlex.
- Endocytosis and trans-Golgi Network in Yeast.Sub-cellular biochemistry · 2026Review
- A tale of Rabs and the exocyst complex in ciliary trafficking and biogenesis.Frontiers in cell and developmental biology · 2025Review
- The exocyst in context.Biochemical Society transactions · 2024Review
- PyF2F: a robust and simplified fluorophore-to-fluorophore distance measurement tool for Protein interactions from Imaging Complexes after Translocation experiments.NAR genomics and bioinformatics · 2024Article
- Osh-dependent and -independent Regulation of PI4P Levels During Polarized Growth ofMolecular biology of the cell · 2023Article
- Exploring the consequences of redirecting an exocytic Rab onto endocytic vesicles.Molecular biology of the cell · 2023Article
- Who's in control? Principles of Rab GTPase activation in endolysosomal membrane trafficking and beyond.The Journal of cell biology · 2021Review
- Insects defend against fungal infection by employing microRNAs to silence virulence-related genes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Direct trafficking pathways from the Golgi apparatus to the plasma membrane.Seminars in cell & developmental biology · 2020Review
- The Role of Secretory Pathways inJournal of fungi (Basel, Switzerland) · 2020Review
- Autoactivation of small GTPases by the GEF-effector positive feedback modules.F1000Research · 2019Review
- Polarized Exocytosis.Cold Spring Harbor perspectives in biology · 2017Review
- The exocytic Rabs Ypt3 and Ypt2 regulate the early step of biogenesis of the spore plasma membrane in fission yeast.Molecular biology of the cell · 2016Article
- Regulation of membrane traffic by Rab GEF and GAP cascades.Small GTPases · 2016Review
- The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p.Molecular biology of the cell · 2016Article
- Probing Functional Changes in Exocyst Configuration with Monoclonal Antibodies.Frontiers in cell and developmental biology · 2016Article
- The Secret Life of Tethers: The Role of Tethering Factors in SNARE Complex Regulation.Frontiers in cell and developmental biology · 2016Review
- DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.The Journal of cell biology · 2015Article
- Article
- In Candida albicans hyphae, Sec2p is physically associated with SEC2 mRNA on secretory vesicles.Molecular microbiology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activation of the rab GTPase, Sec4p, by its exchange factor, Sec2p, is needed for polarized transport of secretory vesicles to exocytic sites and for exocytosis. A small region in the C-terminal half of Sec2p regulates its localization. Loss of this region results in temperature-sensitive growth and the depolarized accumulation of secretory vesicles. Here, we show that Sec2p associates with the exocyst, an octameric effector of Sec4p involved in tethering secretory vesicles to the plasma membrane. Specifically, the exocyst subunit Sec15p directly interacts with Sec2p. This interaction normally occurs on secretory vesicles and serves to couple nucleotide exchange on Sec4p to the recruitment of the Sec4p effector. The mislocalization of Sec2p mutants correlates with dramatically enhanced binding to the exocyst complex. We propose that Sec2p is normally released from the exocyst after vesicle tethering so that it can recycle onto a new round of vesicles. The mislocalization of Sec2p mutants results from a failure to be released from Sec15p, blocking this recycling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.