ArticleThe American journal of pathology1991
Expression of alpha 2,6-linked sialic acid residues in neoplastic but not in normal human colonic mucosa. A lectin-gold cytochemical study with Sambucus nigra and Maackia amurensis lectins.
Article in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 144 citations in OpenAlex.
- Expression of 9-Life (Basel, Switzerland) · 2025Article
- Sialic Acid Receptor Specificity in Mammary Gland of Dairy Cattle Infected with Highly Pathogenic Avian Influenza A(H5N1) Virus.Emerging infectious diseases · 2024Article
- EarlyFrontiers in oncology · 2024Article
- When a negative (charge) is not a positive: sialylation and its role in cancer mechanics and progression.Frontiers in oncology · 2024Review
- High-MannoseCancers · 2022Article
- Review
- Regulation of ST6GAL1 sialyltransferase expression in cancer cells.Glycobiology · 2021Review
- Review
- N-Glycomic Signature of Stage II Colorectal Cancer and Its Association With the Tumor Microenvironment.Molecular & cellular proteomics : MCP · 2021Article
- Metabolic Glycoengineering Enables the Ultrastructural Visualization of Sialic Acids in the Glycocalyx of the Alveolar Epithelial Cell Line hAELVi.Frontiers in bioengineering and biotechnology · 2020Article
- Glycosylation in health and disease.Nature reviews. Nephrology · 2019Review
- Mahanine drives pancreatic adenocarcinoma cells into endoplasmic reticular stress-mediated apoptosis through modulating sialylation process and CaScientific reports · 2018Article
- Exploration of the Sialic Acid World.Advances in carbohydrate chemistry and biochemistry · 2018Review
- Structure aided design of a Neu5Gc specific lectin.Scientific reports · 2017Article
- Expression and function of NKp46 W32R: the human homologous protein of mouse NKp46 W32R (Noé).Scientific reports · 2017Article
- Significance of β-Galactoside α2,6 Sialyltranferase 1 in Cancers.Molecules (Basel, Switzerland) · 2015Review
- Identification of putative novel O-glycosylations in the NK killer receptor Ncr1 essential for its activity.Cell discovery · 2015Article
- An oncogenic protein Golgi phosphoprotein 3 up-regulates cell migration via sialylation.The Journal of biological chemistry · 2014Article
- Associated expression of α2,3sialylated type 2 chain structures with lymph node metastasis in distal colorectal cancer.Surgery today · 2013Article
- Colonic carcinogenesis along different genetic routes: glycophenotyping of tumor cases separated by microsatellite instability/stability.Histochemistry and cell biology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased sialylation of cell surface glycoconjugates has been demonstrated in malignant tumors and shown to be correlated with the invasive and metastatic growth of colon carcinoma cells. The authors have applied the Maackia amurensis lectin, which interacts with alpha 2,3-linked sialic acid, and the Sambucus nigra I lectin specific for alpha 2,6-linked sialic acid. In human colon, alpha 2,3-linked sialic acid was detectable in normal and transitional mucosa as well as in adenomas with different degrees of dysplasia and in carcinoma. In contrast, alpha 2,6-linked sialic acid as visualized with Sambucus nigra I lectin was found only in severe dysplasia and carcinoma. Thus expression of binding sites for Sambucus nigra I lectin was associated with the occurrence of histologic features of malignancy. It is concluded that malignant transformation in human colonic epithelium is accompanied by the de novo expression of an alpha 2,6 sialyl-transferase. These findings provide the basis for more detailed studies of the possible role of cell surface glycoconjugates bearing alpha 2,6-linked sialic acid in growth behavior of human colonic epithelial cells.
Indexed as
Identifiers
1661075PMC1886452W56002507What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.