ArticleThe American journal of pathology1991
Epstein-Barr virus and Hodgkin's disease. A correlative in situ hybridization and polymerase chain reaction study.
Article in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.Nature communications · 2014Pooled it
- Review
- Magnetic resonance imaging of methotrexate-related lymphoproliferative disorder with a chief complaint of oral symptoms.Oral radiology · 2023Article
- Epstein-Barr Virus-Oral Bacterial Link in the Development of Oral Squamous Cell Carcinoma.Pathogens (Basel, Switzerland) · 2020Review
- Molecular Epidemiology of Epstein-Barr virus (EBV) in Patients with Hematologic Malignancies.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Tracking EBV-encoded RNAs (EBERs) from the nucleus to the excreted exosomes of B-lymphocytes.Scientific reports · 2018Article
- Oral Methotrexate-related Lymphoproliferative Disease Presenting with Severe Osteonecrosis of the Jaw: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2018Review
- Epstein-Barr virus-encoded RNAs (EBERs) complement the loss of Herpesvirus telomerase RNA (vTR) in virus-induced tumor formation.Scientific reports · 2018Article
- Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma.The Journal of pathology · 2017Article
- Immunotherapy against cancer-related viruses.Cell research · 2017Review
- Epstein- Barr Virus: Clinical and Epidemiological Revisits and Genetic Basis of Oncogenesis.The open virology journal · 2015Article
- Study of Epstein-Barr virus expression in Burkitt's lymphoma by polymerase chain reaction and in situ hybridization: A study in Iran.Dental research journal · 2014Article
- EBV may be expressed in the LP cells of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) in both children and adults.The American journal of surgical pathology · 2014Article
- Epstein-Barr virus patterns in US Burkitt lymphoma tumors from the SEER residual tissue repository during 1979-2009.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2014Article
- Epstein-Barr virus-encoded small RNAs (EBERs) are present in fractions related to exosomes released by EBV-transformed cells.PloS one · 2014Article
- Evidence of an oncogenic gammaherpesvirus in domestic dogs.Virology · 2012Article
- A protective role for early oral exposures in the etiology of young adult Hodgkin lymphoma.Blood · 2009Article
- Age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorders: special references to lymphomas surrounding this newly recognized clinicopathologic disease.Cancer science · 2008Review
- Contribution of the Epstein Barr virus to the molecular pathogenesis of Hodgkin lymphoma.Journal of clinical pathology · 2007Review
- Proliferating cell nuclear antigen (PCNA), p53 and MDM2 expression in Hodgkins disease.Sao Paulo medical journal = Revista paulista de medicina · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The authors studied typical Hodgkin's disease along with the nodular, lymphocyte predominance subtype by both the polymerase chain reaction (PCR) and in situ hybridization for evidence of the Epstein-Barr virus (EBV). By PCR, EBV DNA was detected in 12/23 cases of typical Hodgkin's disease and 2/13 cases of the nodular, lymphocyte predominance subtype. EBV RNA was detected by in situ hybridization studies within Reed-Sternberg cells and variants in 11/23 cases of typical Hodgkin's disease and 0/13 cases of nodular, lymphocyte predominance Hodgkin's disease. Other cells positive for EBV, identified as both B and T cells in double-labeling immunohistochemical/in situ hybridization studies, were found in 20/23 cases of typical Hodgkin's disease, 9/13 cases of nodular, lymphocyte predominance Hodgkin's disease, 4/6 cases of progressive transformation of germinal centers, and 7/10 normal lymphoid tissues. It is concluded that EBV is significantly associated with Reed-Sternberg cells in approximately one-half cases of typical Hodgkin's disease but not in the nodular, lymphocyte predominance subtype. EBV-infected B and T cells are also present in a majority of cases of Hodgkin's disease as well as in reactive conditions.
Indexed as
Identifiers
1661073PMC1886470What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.