ReviewThe American journal of pathology1991
Warner-Lambert/Parke-Davis Award Lecture. Viral pathogenesis of atherosclerosis. Impact of molecular mimicry and viral genes.
Review in The American journal of pathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 90 citations in OpenAlex.
- Viral infection and atherosclerosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Review
- Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature.BMC geriatrics · 2014Review
- A study of arteriosclerosis in healthy subjects with HBV and HCV infection.Journal of gastroenterology · 2005Article
- Induction of syncytia by neuropathogenic murine leukemia viruses depends on receptor density, host cell determinants, and the intrinsic fusion potential of envelope protein.Journal of virology · 1999Article
- Clonal architecture of normal and atherosclerotic aorta: implications for atherogenesis and vascular development.The American journal of pathology · 1998Article
- Coagulation initiated on herpesviruses.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Transformation of rabbit vascular smooth muscle cells by human cytomegalovirus morphological transforming region I.The American journal of pathology · 1997Article
- Respiratory infection in lipid-fed rabbits enhances sudanophilia and the expression of VCAM-1.The American journal of pathology · 1997Article
- Monoclonality of smooth muscle cells in human atherosclerosis.The American journal of pathology · 1997Article
- Cytoplasmic sequestration of p53 in cytomegalovirus-infected human endothelial cells.The American journal of pathology · 1996Article
- Impaired arterial reactivity following cytomegalovirus infection in the immunosuppressed rat.British journal of pharmacology · 1996Article
- Recurrent herpes labialis as a potential risk factor for nonarteritic anterior ischemic optic neuropathy.Journal of the National Medical Association · 1996Article
- Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia.The Journal of clinical investigation · 1995Article
- In vitro susceptibility of human vascular wall cells to infection with Chlamydia pneumoniae.Journal of clinical microbiology · 1995Article
- Lessons for atherosclerosis research from tuberculosis and peptic ulcer.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 1995Article
- Membrane related effects in endothelial cells induced by human cytomegalovirus.Archives of virology · 1995Article
- Triple drug immunosuppression significantly reduces immune activation and allograft arteriosclerosis in cytomegalovirus-infected rat aortic allografts and induces early latency of viral infection.The American journal of pathology · 1994Article
- Acute cytomegalovirus infection induces a subendothelial inflammation (endothelialitis) in the allograft vascular wall. A possible linkage with enhanced allograft arteriosclerosis.The American journal of pathology · 1994Article
- Rous-Whipple Award Lecture. Atherosclerosis: a defense mechanism gone awry.The American journal of pathology · 1993Review
- Cytomegalovirus infection enhances smooth muscle cell proliferation and intimal thickening of rat aortic allografts.The Journal of clinical investigation · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human atherogenesis is a pleiotropic process with an undefined cause. Several pathologic factors have been linked to the disease process, including arterial injury or activation of the endothelium, which may injury or activation of the endothelium, which may initiate proatherosclerotic events in the vessel wall. Atherosclerotic lesions are characterized, in part, by the presence of activated immune cells, abnormal cell proliferation, and altered cholesterol metabolism. These activated immunocompetent cells in plaques produce vasoactive mediators that can alter homeostasis and may promote the arteriopathy. Both molecular and structural evidence is presented that herpesviruses, by way of induction of altered gene function and cellular cholesterol metabolism, coupled with their ability to activate coagulation and a monocyte receptor on the infected endothelium, are involved in major pathogenic events associated with atherosclerosis and thrombosis. Work from the author's laboratory, as well as from other research groups, have shown that avian and human herpesviruses act specifically to induce alterations to the surface and inner layers of the blood vessel wall that may predispose to atherosclerosis and its attendant clinical complications.
Indexed as
Identifiers
1661071PMC1886453W1901409510What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.