ArticleVirchows Archiv. A, Pathological anatomy and histopathology1991
Hyperplasia and hypertrophy of Leydig cells associated with testicular germ cell tumours containing syncytiotrophoblastic giant cells.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 8 citations in OpenAlex.
- Article
- The role of G-protein-coupled membrane estrogen receptor in mouse Leydig cell function-in vivo and in vitro evaluation.Cell and tissue research · 2018Article
- Chronic low-dose exposure to a mixture of environmental endocrine disruptors induces microRNAs/isomiRs deregulation in mouse concomitant with intratesticular estradiol reduction.Scientific reports · 2017Article
- An autopsy case of primary mixed choriocarcinoma and mature teratoma located in the thymic region associated with elevated human chorionic gonadotropin levels and characteristic testicular changes.Medical molecular morphology · 2006Article
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2 authors at 1 institution in 1 country.
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Abstract
In patients with seminomas and non-seminomatous germ cell tumours of the testis syncytiotrophoblastic giant cells (STGC) are largely responsible for elevated levels of chorionic gonadotropin. In searching for these cells, the question arises whether hyperplasia and/or hypertrophy of Leydig cells in the adjacent testicular tissue is a relevant finding. To elucidate this problem we analysed the tumour-free testicular tissue of 20 seminomas and 20 combined seminomatous and non-seminomatous germ cell tumours with or without immunohistochemically demonstrable STGC morphometrically. Extension of Leydig cell areas and the surface areas of Leydig cells per tubule are increased significantly in seminomas and combined tumours when STGC are present. There is also an apparent increase in the number of Leydig cells per tubule in seminomas and combined germ cell tumours with STGC. The difference, however, is not significant statistically in the group of seminomas. Hypertrophy and/or hyperplasia of Leydig cells must be considered as a relevant finding in germ cell tumours with STGC. It is most easily recorded by evaluating the surface area of Leydig cells per test area or per tubule.
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