ArticleWorld journal of gastroenterology2006
Liver cell adenoma: a case report with clonal analysis and literature review.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Benign Liver Tumors.Visceral medicine · 2020Review
- Oestrogen hormone receptors in focal nodular hyperplasia.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2015Article
- Skewed X-chromosome inactivation in patients with esophageal carcinoma.Diagnostic pathology · 2013Article
- Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma.World journal of gastroenterology · 2009Article
- A case of hepatocellular carcinoma arising within large focal nodular hyperplasia with review of the literature.World journal of gastroenterology · 2006Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a case of liver cell adenoma (LCA) in a 33-year-old female patient with special respect to its clonality status, pathogenic factors and differential diagnosis. The case was examined by histopathology, immunohistochemistry and a clonality assay based on X-chromosomal inactivation mosaicism in female somatic tissues and polymorphism at androgen receptor focus. The clinicopathological features of the reported cases from China and other countries were compared. The lesion was spherical, sizing 2 cm in its maximal dimension. Histologically, it was composed of cells arranged in cords, most of which were two-cell-thick and separated by sinusoids. Focal fatty change and excessive glycogen storage were observed. The tumor cells were round or polygonal in shape, resembling the surrounding parenchymal cells. Mitosis was not found. No portal tract, central vein or ductule was found within the lesion. The tumor tissue showed a positive reaction for cytokeratin (CK) 18, but not for CK19, vimentin, estrogen and progesterone receptors. Monoclonality was demonstrated for the lesion, confirming the diagnosis of an LCA. Clonality analysis is helpful for its distinction from focal nodular hyperplasia.
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