ArticleWorld journal of gastroenterology2006
Liver fibrosis and tissue architectural change measurement using fractal-rectified metrics and Hurst's exponent.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Enhancing liver fibrosis measurement: Deep learning and uncertainty analysis across multi-center cohorts.Journal of pathology informatics · 2026Article
- Fractal nature of human gastrointestinal system: Exploring a new era.World journal of gastroenterology · 2023Review
- PD-L1, fibrosis, and immunotherapy in hepatocellular carcinoma: the importance of a scientific method to explore observations and answer questions.Surgery today · 2020Article
- The Complexity and Fractal Geometry of Nuclear Medicine Images.Molecular imaging and biology · 2019Review
- Computer-aided assessment of the extra-cellular matrix during pancreatic carcinogenesis: a pilot study.Journal of translational medicine · 2019Article
- Morphology of the pancreas in type 2 diabetes: effect of weight loss with or without normalisation of insulin secretory capacity.Diabetologia · 2016Article
- Fractal Dimension in Quantifying Experimental-Pulmonary-Hypertension-Induced Cardiac Dysfunction in Rats.Arquivos brasileiros de cardiologia · 2016Article
- Changes in dermal matrix in the absence of Rac1 in keratinocytes.Journal of anatomy · 2016Article
- Nitric Oxide Modulates Postnatal Bone Marrow-Derived Mesenchymal Stem Cell Migration.Frontiers in cell and developmental biology · 2016Article
- A New Image Analysis Method Based on Morphometric and Fractal Parameters for Rapid Evaluation of In Situ Mammalian Mast Cell Status.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2015Article
- Diagnosis system for hepatocellular carcinoma based on fractal dimension of morphometric elements integrated in an artificial neural network.BioMed research international · 2014Article
- Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL).Hepatology international · 2009Article
- Metrically measuring liver biopsy: a chronic hepatitis B and C computer-aided morphologic description.World journal of gastroenterology · 2008Article
- Sampling variability of computer-aided fractal-corrected measures of liver fibrosis in needle biopsy specimens.World journal of gastroenterology · 2006Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo provide the accurate alternative metrical means of monitoring the effects of new antiviral drugs on the reversal of newly formed collagen.
methodsDigitized histological biopsy sections taken from 209 patients with chronic C virus hepatitis with different grade of fibrosis or cirrhosis, were measured by means of a new, rapid, user-friendly, fully computer-aided method based on the international system meter rectified using fractal principles.
resultsThe following were described: geometric perimeter, area and wrinkledness of fibrosis; the collation of the Knodell, Sheuer, Ishak and METAVIR scores with fractal-rectified metric measurements; the meaning of the physical composition of fibrosis in relation to the magnitude of collagen islets; the intra- and inter-biopsy sample variability of these parameters; the"staging" of biopsy sections indicating the pathway covered by fibrosis formation towards its maximum known value; the quantitative liver tissue architectural changes with the Hurst exponent.
conclusionOur model provides the first metrical evaluations of the geometric properties of fibrosis and the quantitative architectural changes of the liver tissue. The representativeness of histological sections of the whole liver is also discussed in the light of the results obtained with the Hurst coefficient.
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