ArticleProceedings. Biological sciences2006
Evaluating bacterial pathogen DNA preservation in museum osteological collections.
Article in Proceedings. Biological sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Diagnostic Methods Used in Detecting Syphilis in Paleopathological Research-A Literature Review.Diagnostics (Basel, Switzerland) · 2025Review
- The past, present and future of ancient bacterial DNA.Microbial genomics · 2020Review
- First Paleogenetic Evidence of Probable Syphilis and Treponematoses Cases in the Brazilian Colonial Period.BioMed research international · 2018Article
- Article
- Ancient pathogens in museal dry bone specimens: analysis of paleocytology and aDNA.Wiener medizinische Wochenschrift (1946) · 2015Article
- Screening ancient tuberculosis with qPCR: challenges and opportunities.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- False positives complicate ancient pathogen identifications using high-throughput shotgun sequencing.BMC research notes · 2014Article
- Infectious disease, endangerment, and extinction.International journal of evolutionary biology · 2013Article
- Neonate human remains: a window of opportunity to the molecular study of ancient syphilis.PloS one · 2012Article
- Plague genome: The Black Death decoded.Nature · 2011Article
- Article
- Rapid evolution and the importance of recombination to the gastroenteric pathogen Campylobacter jejuni.Molecular biology and evolution · 2009Article
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Authors and funding
2 authors.
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Abstract
Reports of bacterial pathogen DNA sequences obtained from archaeological bone specimens raise the possibility of greatly improving our understanding of the history of infectious diseases. However, the survival of pathogen DNA over long time periods is poorly characterized, and scepticism remains about the reliability of these data. In order to explore the survival of bacterial pathogen DNA in bone specimens, we analysed samples from 59 eighteenth and twentieth century individuals known to have been infected with either Mycobacterium tuberculosis or Treponema pallidum. No reproducible evidence of surviving pathogen DNA was obtained, despite the use of extraction and PCR-amplification methods determined to be highly sensitive. These data suggest that previous studies need to be interpreted with caution, and we propose that a much greater emphasis is placed on understanding how pathogen DNA survives in archaeological material, and how its presence can be properly verified and used.
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