Evidence map›Paper›PMID 16608509›Full record

ArticleBMC infectious diseases2006

Successful treatment of Candida parapsilosis mural endocarditis with combined caspofungin and voriconazole.

Víctor López-Ciudad, María J Castro-Orjales, Cristóbal León, César Sanz-Rodríguez, María J de la Torre-Fernández, Miguel A Pérez de Juan-Romero, María D Collell-Llach, María D Díaz-López

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Guideline
  2. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009
    Guideline
  3. Case reports in infectious diseases · 2025
    Article
  4. ISCCM Position Statement on the Management of Invasive Fungal Infections in the Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  5. Contemporary comparison of infective endocarditis caused by Candida albicans and Candida parapsilosis: a cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022
    Article
  6. Article
  7. Role of Antifungal Combinations in Difficult to TreatJournal of fungi (Basel, Switzerland) · 2021
    Review
  8. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021
    Article
  9. Article
  10. Candida parapsilosis prosthetic valve endocarditis.Medical mycology case reports · 2015
    Article
  11. Observational
  12. Article
  13. Review
  14. Article
  15. Article
  16. Combination antifungal therapy: from bench to bedside.Current infectious disease reports · 2008
    Article
  17. Candida parapsilosis, an emerging fungal pathogen.Clinical microbiology reviews · 2008
    Review
  18. Candida infective endocarditis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2008
    Article
  19. Fungal endocarditis.Current infectious disease reports · 2008
    Article
  20. Candida parapsilosis endocarditis: a comparative review of the literature.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2007
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Víctor López-CiudadIntensive Care Unit, Hospital Santa María Madre-Complejo Hospitalario de Ourense, Ourense, Spain. victor.jose.lopez.ciudad@sergas.es
María J Castro-Orjales
Cristóbal León
César Sanz-Rodríguez
María J de la Torre-Fernández
Miguel A Pérez de Juan-Romero
María D Collell-Llach
María D Díaz-López
Complejo Hospitalario de Ourense · ESHospital Universitario de Valme · ESMSD (Spain) · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFungal mural endocarditis is a rare entity in which the antemortem diagnosis is seldom made. Seven cases of mural endocarditis caused by Candida spp. have been collected from literature and six of these patients died after treatment with amphotericin B. CASE PRESENTATION: We report a case of mural endocarditis diagnosed by transesophageal echocardiogram and positive blood cultures to Candida parapsilosis. Because blood cultures continued to yield C. parapsilosis despite caspofungin monotherapy, treatment with voriconazole was added.

conclusionThis is the first description of successful treatment of C. parapsilosis mural endocarditis with caspofungin and voriconazole.

Indexed as

Antifungal AgentsCandidiasisCaspofunginDrug Therapy, CombinationEchinocandinsEndocarditisFemaleHumansLipopeptidesMiddle AgedPeptides, CyclicPyrimidinesTreatment OutcomeTriazolesVoriconazoleAntifungal AgentsCaspofunginEchinocandinsLipopeptidesPeptides, CyclicPyrimidinesTriazolesVoriconazole

Identifiers

PMID16608509
PMCPMC1458348
OpenAlexW2159394449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.