ArticleProceedings of the National Academy of Sciences of the United States of America2006
Breakpoint structure reveals the unique origin of an interspecific chromosomal inversion (2La) in the Anopheles gambiae complex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67 citing papers in PubMed.
- Chromosomal inversions modulate 3D chromatin interactions and regulatory architecture inResearch square · 2026Article
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- Chromosomal rearrangements in mosquitoes: from micro- to macroevolution.Current opinion in insect science · 2025Review
- Effects of temperature and nutrition stress on Anopheles stephensi, an Indian urban malaria vector.Malaria journal · 2025Article
- Chromosomal Inversions and Their Potential Impact on the Evolution of Arboviral Vector Aedes aegypti.Genome biology and evolution · 2025Article
- The origin and maintenance of supergenes contributing to ecological adaptation in Atlantic herring.Nature communications · 2024Article
- Two Nested Inversions in the X Chromosome Differentiate the Dominant Malaria Vectors in Europe,Insects · 2024Article
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- Identification of a TNF-TNFR-like system in malaria vectors (Anopheles stephensi) likely to influence Plasmodium resistance.Scientific reports · 2022Article
- The genome trilogy of Anopheles stephensi, an urban malaria vector, reveals structure of a locus associated with adaptation to environmental heterogeneity.Scientific reports · 2022Article
- Transposable element variants and their potential adaptive impact in urban populations of the malaria vectorGenome research · 2022Article
- Article
- Inversion breakpoints and the evolution of supergenes.Molecular ecology · 2021Review
- Chromosome-level genome assemblies of the malaria vectors Anopheles coluzzii and Anopheles arabiensis.GigaScience · 2021Article
- Evaluating the probability of CRISPR-based gene drive contaminating another species.Evolutionary applications · 2020Article
- Fine-Scale Position Effects Shape the Distribution of Inversion Breakpoints in Drosophila melanogaster.Genome biology and evolution · 2020Article
- Recent advances and future perspectives in vector-omics.Current opinion in insect science · 2020Review
- Highly specific PCR-RFLP assays for karyotyping the widespread 2Rb inversion in malaria vectors of the Anopheles gambiae complex.Parasites & vectors · 2020Article
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Abstract
Paracentric chromosomal inversions are major architects of organismal evolution and have been associated with adaptations relevant to malaria transmission in anopheline mosquitoes. The processes responsible for their origin and maintenance, still poorly understood, can be illuminated by analysis of inversion breakpoint sequences. Here, we report the breakpoint structure of chromosomal inversion 2La from the principal malaria vector Anopheles gambiae and its relatives in the A. gambiae complex. The distal and proximal breakpoints of the standard (2L+a) arrangement contain gene duplications: full-length genes and their truncated copies at opposite ends. Intact genes without pseudogene copies in the alternative arrangement (2La) imply that 2L+a is derived and was viable despite damage to genes, because duplication preserved gene function. A unique origin for the interspecific 2La inversion was challenged previously by indirect genetic evidence, but breakpoint sequences determined from members of the A. gambiae complex strongly suggest their descent from a single event. The derived position of 2L+a, long considered ancestral in this medically important group, has significant implications for the phylogenetic history and the evolution of vectorial capacity in the A. gambiae complex.
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