ArticleProceedings of the National Academy of Sciences of the United States of America2006
CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- The myonuclear domain in adult skeletal muscle fibres: past, present and future.The Journal of physiology · 2023Review
- Multiplexed RNAscope and immunofluorescence on whole-mount skeletal myofibers and their associated stem cells.Development (Cambridge, England) · 2019Article
- Coding Cell Identity of Human Skeletal Muscle Progenitor Cells Using Cell Surface Markers: Current Status and Remaining Challenges for Characterization and Isolation.Frontiers in cell and developmental biology · 2019Review
- Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death.Cell reports · 2017Article
- CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease.PloS one · 2017Article
- Diverging roles for Lrp4 and Wnt signaling in neuromuscular synapse development during evolution.Genes & development · 2016Article
- Nuclear positioning in muscle development and disease.Frontiers in physiology · 2013Review
- Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14.American journal of physiology. Cell physiology · 2012Article
- Axonal regeneration and neuronal function are preserved in motor neurons lacking ß-actin in vivo.PloS one · 2011Article
- Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Identification of the neuromuscular junction transcriptome of extraocular muscle by laser capture microdissection.Investigative ophthalmology & visual science · 2010Article
- Loss of CD24 expression promotes ductal branching in the murine mammary gland.Cellular and molecular life sciences : CMLS · 2010Article
- To build a synapse: signaling pathways in neuromuscular junction assembly.Development (Cambridge, England) · 2010Review
- Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy.Human molecular genetics · 2008Article
- Selective targeting of different neural cell adhesion molecule isoforms during motoneuron myotube synapse formation in culture and the switch from an immature to mature form of synaptic vesicle cycling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The genes encoding several synaptic proteins, including acetylcholine receptors, acetylcholinesterase, and the muscle-specific kinase, MuSK, are expressed selectively by a small number of myofiber nuclei positioned near the synaptic site. Genetic analysis of mutant mice suggests that additional genes, expressed selectively by synaptic nuclei, might encode muscle-derived retrograde signals that regulate the differentiation of motor axon terminals. To identify candidate retrograde signals, we used a microarray screen to identify genes that are preferentially expressed in the synaptic region of muscle, and we analyzed one such gene, CD24, further. We show that CD24, which encodes a small, variably and highly glycosylated, glycosylphosphatidylinositol (GPI)-linked protein, is expressed preferentially by myofiber synaptic nuclei in embryonic and adult muscle, and that CD24 expression is restricted to the central region of muscle independent of innervation. Moreover, we show that CD24 has a role in presynaptic differentiation, because synaptic transmission is depressed and fails entirely, in a cyclical manner, after repetitive stimulation of motor axons in CD24 mutant mice. These deficits in synaptic transmission, which are accompanied by aberrant stimulus-dependent uptake of AM1-43 from axons, indicate that CD24 is required for normal presynaptic maturation and function. Because CD24 is also expressed in some neurons, additional experiments will be required to determine whether pre- or postsynaptic CD24 mediates these effects on presynaptic development and function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.