ArticleGenome research2006
A preliminary comparative analysis of primate segmental duplications shows elevated substitution rates and a great-ape expansion of intrachromosomal duplications.
Article in Genome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 90 citations in OpenAlex.
- Reconstruction of Segmental Duplication Rates and Associated Genomic Features by Network Analysis.Genome biology and evolution · 2025Article
- Structural polymorphism and diversity of human segmental duplications.Nature genetics · 2025Article
- Independent expansion, selection and hypervariability of thebioRxiv : the preprint server for biology · 2024Article
- Modelling segmental duplications in the human genome.BMC genomics · 2021Article
- Article
- Improved assembly and variant detection of a haploid human genome using single-molecule, high-fidelity long reads.Annals of human genetics · 2020Article
- Gene Fusions Derived by Transcriptional Readthrough are Driven by Segmental Duplication in Human.Genome biology and evolution · 2019Article
- Article
- Human gene copy number variation and infectious disease.Human genetics · 2014Review
- Distribution of segmental duplications in the context of higher order chromatin organisation of human chromosome 7.BMC genomics · 2014Article
- A common 56-kilobase deletion in a primate-specific segmental duplication creates a novel butyrophilin-like protein.BMC genetics · 2013Article
- Evolutionary dynamism of the primate LRRC37 gene family.Genome research · 2013Article
- A common copy-number breakpoint of ERBB2 amplification in breast cancer colocalizes with a complex block of segmental duplications.Breast cancer research : BCR · 2012Article
- Regulatory element copy number differences shape primate expression profiles.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Exploring the role of copy number variants in human adaptation.Trends in genetics : TIG · 2012Review
- Identification and characterization of lineage-specific highly conserved noncoding sequences in Mammalian genomes.Genome biology and evolution · 2012Article
- Genomic structure and evolution of multigene families: "flowers" on the human genome.International journal of evolutionary biology · 2012Article
- Transcriptional variations mediated by an alternative promoter of the FPR3 gene.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Increased de novo copy number variants in the offspring of older males.Translational psychiatry · 2011Article
- Variation in DNA substitution rates among lineages erroneously inferred from simulated clock-like data.PloS one · 2010Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Compared with other sequenced animal genomes, human segmental duplications appear larger, more interspersed, and disproportionately represented as high-sequence identity alignments. Global sequence divergence estimates of human duplications have suggested an expansion relatively recently during hominoid evolution. Based on primate comparative sequence analysis of 37 unique duplication-transition regions, we establish a molecular clock for their divergence that shows a significant increase in their effective substitution rate when compared with unique genomic sequence. Fluorescent in situ hybridization (FISH) analyses from 1053 random nonhuman primate BACs indicate that great-ape species have been enriched for interspersed segmental duplications compared with representative Old World and New World monkeys. These findings support computational analyses that show a 12-fold excess of recent (>98%) intrachromosomal duplications when compared with duplications between nonhomologous chromosomes. These architectural shifts in genomic structure and elevated substitution rates have important implications for the emergence of new genes, gene-expression differences, and structural variation among humans and great apes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.