ArticleGenome research2006
Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes.
Article in Genome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 82 citations in OpenAlex.
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- Lack of Molecular Mimicry between Nonhuman Primates and Infectious Pathogens: The Possible Genetic Bases.Global medical genetics · 2021Article
- Conserved paradoxical relationships among the evolutionary, structural and expressional features of KRAB zinc-finger proteins reveal their special functional characteristics.BMC molecular and cell biology · 2021Article
- Few SINEs of life: Alu elements have little evidence for biological relevance despite elevated translation.NAR genomics and bioinformatics · 2020Article
- The Role of SINE-VNTR-Alu (SVA) Retrotransposons in Shaping the Human Genome.International journal of molecular sciences · 2019Article
- Endogenous Retroviruses Function as Gene Expression Regulatory Elements During Mammalian Pre-implantation Embryo Development.International journal of molecular sciences · 2019Review
- Zinc-finger domains in metazoans: evolution gone wild.Genome biology · 2017Article
- Non-base-contacting residues enable kaleidoscopic evolution of metazoan C2H2 zinc finger DNA binding.Genome biology · 2017Article
- The pioneering role of PRDM9 indel mutations in tarsier evolution.Scientific reports · 2016Article
- Transcriptional repression of p27 is essential for murine embryonic development.Scientific reports · 2016Article
- Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa).Molecular biology and evolution · 2016Article
- The evolution of gene expression and binding specificity of the largest transcription factor family in primates.Evolution; international journal of organic evolution · 2016Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most genes are conserved in mammals, but certain gene families have acquired large numbers of lineage-specific loci through repeated rounds of gene duplication, divergence, and loss that have continued in each mammalian group. One such family encodes KRAB-zinc finger (KRAB-ZNF) proteins, which function as transcriptional repressors. One particular subfamily of KRAB-ZNF genes, including ZNF91, has expanded specifically in primates to comprise more than 110 loci in the human genome. Genes of the ZNF91 subfamily reside in large gene clusters near centromeric regions of human chromosomes 19 and 7 with smaller clusters or isolated copies in other locations. Phylogenetic analysis indicates that many of these genes arose before the split between the New and Old World monkeys, but the ZNF91 subfamily has continued to expand and diversify throughout the evolution of apes and humans. Paralogous loci are distinguished by divergence within their zinc finger arrays, indicating selection for proteins with different regulatory targets. In addition, many loci produce multiple alternatively spliced transcripts encoding proteins that may serve separate and perhaps even opposing regulatory roles because of the modular motif structure of KRAB-ZNF genes. The tissue-specific expression patterns and rapid structural divergence of ZNF91 subfamily genes suggest a role in determining gene expression differences between species and the evolution of novel primate traits.
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