ArticleThe Journal of cell biology2006
Drosophila melanogaster Scramblases modulate synaptic transmission.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- The First of Us:bioRxiv : the preprint server for biology · 2025Article
- Transient pores in hemifusion diaphragms.Biophysical journal · 2024Article
- Phospholipid scramblase 1: an essential component of the nephrocyte slit diaphragm.Cellular and molecular life sciences : CMLS · 2024Article
- Vav independently regulates synaptic growth and plasticity through distinct actin-based processes.The Journal of cell biology · 2022Article
- Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Identification and characterization of the novel nuclease activity of human phospholipid scramblase 1.BMC biochemistry · 2016Article
- Article
- Phospholipid scramblase-1-induced lipid reorganization regulates compensatory endocytosis in neuroendocrine cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Rare Genomic Variants Link Bipolar Disorder with Anxiety Disorders to CREB-Regulated Intracellular Signaling Pathways.Frontiers in psychiatry · 2013Article
- A presynaptic endosomal trafficking pathway controls synaptic growth signaling.The Journal of cell biology · 2011Article
- DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains.The Journal of cell biology · 2009Article
- Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors.Bioinformatics (Oxford, England) · 2009Article
- Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice.The Journal of cell biology · 2009Article
- Sphingolipids and membrane biology as determined from genetic models.Prostaglandins & other lipid mediators · 2008Review
- Article
- FM 1-43 labeling of synaptic vesicle pools at the Drosophila neuromuscular junction.Methods in molecular biology (Clifton, N.J.) · 2008Article
- Ceramide transfer protein function is essential for normal oxidative stress response and lifespan.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Flagging fusion: Phosphatidylserine signaling in cell-cell fusion.The Journal of biological chemistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Scramblases are a family of single-pass plasma membrane proteins, identified by their purported ability to scramble phospholipids across the two layers of plasma membrane isolated from platelets and red blood cells. However, their true in vivo role has yet to be elucidated. We report the generation and isolation of null mutants of two Scramblases identified in Drosophila melanogaster. We demonstrate that flies lacking either or both of these Scramblases are not compromised in vivo in processes requiring scrambling of phospholipids. Instead, we show that D. melanogaster lacking both Scramblases have more vesicles and display enhanced recruitment from a reserve pool of vesicles and increased neurotransmitter secretion at the larval neuromuscular synapses. These defects are corrected by the introduction of a genomic copy of the Scramb 1 gene. The lack of phenotypes related to failure of scrambling and the neurophysiological analysis lead us to propose that Scramblases play a modulatory role in the process of neurotransmission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.