ReviewThe Journal of experimental medicine2006
Helper T cell differentiation enters a new era: le roi est mort; vive le roi!
Review in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Dual Functions of T Lymphocytes in Breast Carcinoma: From Immune Protection to Orchestrating Tumor Progression and Metastasis.Cancers · 2023Review
- Th2 polarization in target organs is involved in the alleviation of pathological damage mediated by transplanting granulocyte colony-stimulating factor-primed donor T cells.Science China. Life sciences · 2021Article
- Role of CD4International journal of molecular sciences · 2020Review
- Functional and Phenotypic Plasticity of CD4(+) T Cell Subsets.BioMed research international · 2015Review
- Human Th1 dichotomy: origin, phenotype and biologic activities.Immunology · 2014Article
- Metabolic characterization of Leishmania major infection in activated and nonactivated macrophages.Journal of proteome research · 2012Article
- IL-17E, a proinflammatory cytokine, has antitumor efficacy against several tumor types in vivo.Cancer immunology, immunotherapy : CII · 2010Article
- Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury: a review.Expert opinion on drug metabolism & toxicology · 2010Review
- The other T helper cells in asthma pathogenesis.Journal of allergy · 2010Article
- Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation.The Journal of experimental medicine · 2009Article
- Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis.Journal of neuroinflammation · 2009Article
- Characterisation of effector mechanisms at the host:parasite interface during the immune response to tissue-dwelling intestinal nematode parasites.International journal for parasitology · 2009Review
- Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses.Results and problems in cell differentiation · 2009Review
- Allergy, asthma, and inflammation: which inflammatory cell type is more important?Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2008Article
- BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells.Molecular and cellular biology · 2008Article
- The role of interleukin-12 in the heavy metal-elicited immunomodulation: relevance of various evaluation methods.Journal of occupational medicine and toxicology (London, England) · 2008Article
- The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6.The Journal of clinical investigation · 2008Article
- Alternatively activated macrophages in helminth infections.Current opinion in immunology · 2007Review
- The contribution of immunology to the rational design of novel antibacterial vaccines.Nature reviews. Microbiology · 2007Review
- T lymphocytes in Sjögren's syndrome: contributors to and regulators of pathophysiology.Clinical reviews in allergy & immunology · 2007Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In the dark ages of T cell biology, we considered two fates for differentiated CD4+ T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17-related cytokine IL-25 is essential for Th2 responses in two infectious disease models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.