ArticleThe Journal of experimental medicine2006
Physiological pathway of differentiation of hematopoietic stem cell population into mural cells.
Article in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture.Journal of tissue engineering and regenerative medicine · 2013Trial
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- Evaluation of Relationship between Serum Liver Enzymes and Hypertension: A Cross-Sectional Study Based on Data from Rafsanjan Cohort Study.International journal of hypertension · 2022Article
- Combined administration of laminin-221 and prostacyclin agonist enhances endogenous cardiac repair in an acute infarct rat heart.Scientific reports · 2021Article
- Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization.Scientific reports · 2021Article
- Associations between handgrip strength and hypertension in relation to circulating CD34-positive cell levels among Japanese older men: a cross-sectional study.Environmental health and preventive medicine · 2021Article
- Vascular reconstitution in the tumor for more effective tumor immunotherapy.Cancer science · 2021Review
- A narrative review of central nervous system involvement in acute leukemias.Annals of translational medicine · 2021Review
- Positive Association Between Serum Alkaline Phosphatase and First Stroke in Hypertensive Adults.Frontiers in cardiovascular medicine · 2021Article
- Association Between Alkaline Phosphatase and Clinical Outcomes in Patients With Spontaneous Intracerebral Hemorrhage.Frontiers in neurology · 2021Article
- Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study.Scientific reports · 2020Article
- Association between human T cell leukemia virus 1 (HTLV-1) infection and advanced periodontitis in relation to hematopoietic activity among elderly participants: a cross-sectional study.Environmental health and preventive medicine · 2019Article
- Article
- Handgrip strength and subclinical carotid atherosclerosis in relation to platelet levels among hypertensive elderly Japanese.Oncotarget · 2017Article
- Hemoglobin as a possible biochemical index of hypertension-induced vascular damage.Journal of physiological anthropology · 2016Article
- Association between circulating CD34-positive cells and serum alkaline phosphatase in relation to body mass index for elderly Japanese men.Journal of physiological anthropology · 2016Article
- Association between alkaline phosphatase and hypertension in a rural Japanese population: the Nagasaki Islands study.Journal of physiological anthropology · 2013Article
- microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin.Oncogene · 2013Article
- Requirement of SLD5 for early embryogenesis.PloS one · 2013Article
- Cellularity and structure of fresh human coronary thrombectomy specimens; presence of cells with markers of progenitor cells.Journal of cellular and molecular medicine · 2012Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelial cells (ECs), which are a major component of blood vessels, have been reported to develop in adulthood from hematopoietic cell populations, especially those of the monocyte lineage. Here we show that mural cells (MCs), another component of blood vessels, develop physiologically during embryogenesis from a hematopoietic stem cell (HSC) population, based on the in vitro culture of HSCs and histological examination of acute myeloid leukemia 1 mutant embryos, which lack HSCs. As in the embryo, HSCs in adult bone marrow differentiate into CD45+CD11b+ cells before differentiating into MCs. Moreover, CD45+CD11b+ cells are composed of two populations, CD11bhigh and CD11blow cells, both of which can differentiate into MCs as well as ECs. Interestingly, in a murine ischemia model, MCs and ECs derived from the CD11blow population had a long-term potential to contribute to the formation of newly developed blood vessels in vivo compared with the CD11high population, which could not. Moreover, injection of the CD11bhigh population induced leaky blood vessels, but the CD11blow population did not. With respect to the permeability of vessels, we found that angiopoietin 1, which is a ligand for Tie2 receptor tyrosine kinase expressed on ECs and is suggested to induce cell adhesion between ECs and MCs, is produced by the CD11blow population and plays a critical role in the formation of nonleaky vessels. These observations suggested that the CD11low cell population serves as a good source of cells for in vivo blood vessel regeneration.
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