ArticleImmunogenetics2006
Biased distribution of single nucleotide polymorphisms (SNPs) in porcine Toll-like receptor 1 (TLR1), TLR2, TLR4, TLR5, and TLR6 genes.
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 90 citations in OpenAlex.
- Polymorphisms in Pattern Recognition Receptor Genes Are Associated with Respiratory Disease Severity in Pig Farms.Animals : an open access journal from MDPI · 2022Article
- Identification of a 5-Methylcytosine Site (mC-7) That May InhibitVeterinary sciences · 2022Article
- Therapeutic Targeting of Innate Immune Receptors Against SARS-CoV-2 Infection.Frontiers in pharmacology · 2022Review
- Synonymous and non-synonymous polymorphisms in toll-like receptor 2 (TLR2) gene among complicated measles cases at a tertiary care hospital, Peshawar, Pakistan.Saudi medical journal · 2021Article
- NOD2 Genotypes Affect the Symptoms and Mortality in the Porcine Circovirus 2-Spreading Pig Population.Genes · 2021Article
- Using Linear Discriminant Analysis to Characterize Novel Single Nucleotide Polymorphisms and Expression Profile Changes in Genes of Three Breeds of Rabbit (Comparative medicine · 2021Article
- Regulation and Molecular Mechanism ofAnimals : an open access journal from MDPI · 2019Article
- Polymorphisms of the immune-modulating receptor dectin-1 in pigs: their functional influence and distribution in pig populations.Immunogenetics · 2016Article
- Identification of genetic variation in the swine toll-like receptors and development of a porcine TLR genotyping array.Genetics, selection, evolution : GSE · 2016Article
- Evidence for adaptation of porcine Toll-like receptors.Immunogenetics · 2016Article
- Intestinal Alkaline Phosphatase: Potential Roles in Promoting Gut Health in Weanling Piglets and Its Modulation by Feed Additives - A Review.Asian-Australasian journal of animal sciences · 2016Article
- Article
- Pseudomonas aeruginosa triggers CFTR-mediated airway surface liquid secretion in swine trachea.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The porcine innate immune system: an update.Developmental and comparative immunology · 2014Review
- TLR4 single nucleotide polymorphisms (SNPs) associated with Salmonella shedding in pigs.Journal of applied genetics · 2014Article
- Article
- Association of TLR5 sequence variants and mRNA level with cytokine transcription in pigs.Immunogenetics · 2013Article
- A Whole Genome Association Study to Detect Single Nucleotide Polymorphisms for Blood Components (Immunity) in a Cross between Korean Native Pig and Yorkshire.Asian-Australasian journal of animal sciences · 2012Article
- Large-scale sequencing based on full-length-enriched cDNA libraries in pigs: contribution to annotation of the pig genome draft sequence.BMC genomics · 2012Article
- Association of TLR4 polymorphism with cytokine expression level and pulmonary lesion score in pigs.Molecular biology reports · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) recognize various microbial components and induce immune responses. Polymorphisms in TLRs may influence their recognition of pathogen-derived molecules; swine TLRs are predicted to be associated with responses to infectious diseases such as pneumonia. In this study, we searched for single nucleotide polymorphisms (SNPs) in the coding sequences of porcine TLR1, TLR2, TLR4, TLR5, and TLR6 genes in 96 pigs from 11 breeds and elucidated 21, 11, 7, 13, and 11 SNPs, respectively, which caused amino acid substitutions in the respective TLRs. Distribution of these nonsynonymous SNPs was biased; many were located in the leucine-rich repeats, particularly in TLR1. These data demonstrated that the heterogeneity of TLR genes was preserved in various porcine breeds despite intensive breeding that was carried out for livestock improvement. It suggests that the heterogeneity in TLR genes is advantageous in increasing the possibility of survival in porcine populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.