ArticleVirus genes2006
A gene similar to the human hyaluronan-mediated motility receptor (RHAMM) gene is upregulated during Porcine Circovirus type 2 infection.
Article in Virus genes, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 7 citations in OpenAlex.
- Advances in swine transcriptomics.International journal of biological sciences · 2007Review
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known on the cellular events triggered by the Porcine Circovirus type 2 (PCV2) in Porcine Multisystemic Wasting Syndrome (PMWS). The differential display reverse-transcription PCR (DDRT-PCR) was used to identify cellular target molecules in lymph node tissue that were regulated in PMWS. Comparative profile analysis of a pool of lymph node tissues from PMWS and healthy animals showed that some transcripts were up-regulated in PMWS. Bacterial recombinant clones containing up-regulated transcripts were analyzed by reverse dot blot. Clones showing enhanced hybridization when probed with cDNAs from PMWS animals were sequenced and compared to existing databases. Two of the differentially regulated transcripts displayed homology with human genes such as an RNA splicing factor and hyaluronan-mediated motility receptor (RHAMM). Clones encoding theses genes were subsequently used as probes to analyze their expression pattern in PK15 cells persistently infected with PCV2. Northern blot analyzes indicated that these transcripts were up-regulated in these cells as observed in infected lymph node tissue from PMWS cases. A role for the up-regulation of the RHAMM gene is proposed.
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