ArticleNature structural & molecular biology2006
Nucleophosmin is selectively deposited on mRNA during polyadenylation.
Article in Nature structural & molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- CBRPP: a new RNA-centric method to study RNA-protein interactions.RNA biology · 2021Article
- The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion.Annual review of biochemistry · 2015Review
- Determinants and implications of mRNA poly(A) tail size--does this protein make my tail look big?Seminars in cell & developmental biology · 2014Review
- Poly(A) polymerase (PAP) diversity in gene expression--star-PAP vs canonical PAP.FEBS letters · 2014Review
- Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.Protein science : a publication of the Protein Society · 2013Review
- The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay.PLoS genetics · 2013Article
- Article
- Expression and functional studies on the noncoding RNA, PRINS.International journal of molecular sciences · 2012Article
- Article
- Structure of nucleophosmin DNA-binding domain and analysis of its complex with a G-quadruplex sequence from the c-MYC promoter.The Journal of biological chemistry · 2012Article
- Nucleophosmin deposition during mRNA 3' end processing influences poly(A) tail length.The EMBO journal · 2011Article
- Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases.Oncogene · 2011Review
- NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling.Biochemistry research international · 2011Article
- Chromatin: linking structure and function in the nucleolus.Chromosoma · 2009Review
- Virus-mediated mRNA decay by hyperadenylation.Genome biology · 2009Review
- Fusion of FIP1L1 and RARA as a result of a novel t(4;17)(q12;q21) in a case of juvenile myelomonocytic leukemia.Leukemia · 2007Article
- A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay.The EMBO journal · 2007Article
- Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication.Molecular and cellular biology · 2006Article
- Pre-mRNA 3'-end processing complex assembly and function.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nucleophosmin (NPM), an abundant, predominantly nucleolar protein that influences numerous cellular processes, was shown to specifically associate with the bodies of messenger RNAs as a result of the process of 3'-end formation. NPM deposition requires polyadenylation but not the 3' cleavage event to occur on the transcript. Furthermore, the protein does not associate with RNAs bearing a preformed poly(A) tail or with mRNAs that have undergone cleavage but not polyadenylation. A region within 10 bases upstream of the AAUAAA element is required for NPM association, but deposition of the protein seems to be sequence independent. NPM association with poly(A)(+) mRNAs was also demonstrated in vivo. NPM, therefore, represents a mark left on transcripts as a result of 3'-end processing and may have a role in one or more of a variety of post-transcriptional processes influenced by the polyadenylation event.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.