ArticleBiophysical journal2006
A model for the pulsatile secretion of gonadotropin-releasing hormone from synchronized hypothalamic neurons.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- Modelling KNDy neurons and gonadotropin-releasing hormone pulse generation.Current opinion in endocrine and metabolic research · 2022Review
- Mathematical models in GnRH research.Journal of neuroendocrinology · 2022Review
- Proteomic Analysis of Hypothalamus and Pituitary Gland in Pre and Postpubertal Brahman Heifers.Frontiers in genetics · 2022Article
- Modeling circadian regulation of ovulation timing: age-related disruption of estrous cyclicity.Scientific reports · 2020Article
- Article
- A mathematical model of pulse-coded hormone signal responses in pituitary gonadotroph cells.Mathematical biosciences · 2013Article
- GnRH signaling, the gonadotrope and endocrine control of fertility.Frontiers in neuroendocrinology · 2010Review
- The hypothalamic GnRH pulse generator: multiple regulatory mechanisms.Trends in endocrinology and metabolism: TEM · 2009Review
- An integrated model of electrical spiking, bursting, and calcium oscillations in GnRH neurons.Biophysical journal · 2009Article
- Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons.Endocrinology · 2009Article
- Motivations and methods for analyzing pulsatile hormone secretion.Endocrine reviews · 2008Review
- A mathematical model for the actions of activin, inhibin, and follistatin on pituitary gonadotrophs.Bulletin of mathematical biology · 2008Article
- Emergent synchronous bursting of oxytocin neuronal network.PLoS computational biology · 2008Article
- Facilitation of quantal release induced by a D1-like receptor on bovine chromaffin cells.Biochemistry · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cultured gonadotropin-releasing hormone (GnRH) neurons have been shown to express GnRH receptors. GnRH binding to its receptors activates three types of G-proteins at increasing doses. These G-proteins selectively activate or inhibit GnRH secretion by regulating the intracellular levels of Ca2+ and cAMP. Based on these recent observations, we build a model in which GnRH plays the roles of a feedback regulator and a diffusible synchronizing agent. We show that this GnRH-regulated GnRH-release mechanism is sufficient for generating pulsatile GnRH release. The model reproduces the observed effects of some key drugs that disturb the GnRH pulse generator in specific ways. Simulations of 100 heterogeneous neurons revealed that the synchronization mediated by a common pool of diffusible GnRH is robust. The population can generate synchronized pulsatile signals even when all the individual GnRH neurons oscillate at different amplitudes and peak at different times. These results suggest that the positive and negative effects of the autocrine regulation by GnRH on GnRH neurons are sufficient and robust in generating GnRH pulses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.