ArticleJournal of proteome research2006
Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity.
Article in Journal of proteome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Kappa opioid receptor control of motivated behavior revisited.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Dynorphin participates in interaction between depression and non-erosive reflux disease.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- Histidine, the less interactive cousin of arginine.European journal of mass spectrometry (Chichester, England) · 2019Article
- Mass Spectrometric Imaging of Ceramide Biomarkers Tracks Therapeutic Response in Traumatic Brain Injury.ACS chemical neuroscience · 2017Article
- Mass spectrometry imaging of rat brain lipid profile changes over time following traumatic brain injury.Journal of neuroscience methods · 2016Article
- Dynorphin A analogs for the treatment of chronic neuropathic pain.Future medicinal chemistry · 2016Review
- Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction.Cell death & disease · 2015Article
- MALDI/post ionization-ion mobility mass spectrometry of noncovalent complexes of dopamine receptors' epitopes.Journal of proteome research · 2013Article
- Lateralized response of dynorphin a peptide levels after traumatic brain injury.Journal of neurotrauma · 2012Article
- Estradiol treatment prevents injury induced enhancement in spinal cord dynorphin expression.Frontiers in physiology · 2012Article
- Competition between covalent and noncovalent bond cleavages in dissociation of phosphopeptide-amine complexes.Physical chemistry chemical physics : PCCP · 2011Article
- Glutamate receptor ion channels: structure, regulation, and function.Pharmacological reviews · 2010Review
- Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- 30 years of dynorphins--new insights on their functions in neuropsychiatric diseases.Pharmacology & therapeutics · 2009Review
- How calmodulin interacts with the adenosine A(2A) and the dopamine D(2) receptors.Journal of proteome research · 2008Article
- Endogenous opiates and behavior: 2006.Peptides · 2007Review
- Sulfation, the up-and-coming post-translational modification: its role and mechanism in protein-protein interaction.Journal of proteome research · 2007Article
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 2 countries.
Funding
Abstract
Prodynorphin-derived peptides elicit various pathological effects including neurological dysfunction and cell death. These actions are reduced by N-methyl-d-aspartate receptor (NMDAR) but not opioid receptor antagonists suggesting NMDAR-mediation. Here, we show that a conserved epitope (KVNSEEEEEDA) of the NR1 subunit of the NMDAR binds dynorphin peptides (DYNp) noncovalently. Synthetic peptides containing this epitope form stable complexes with DYNp and prevent the potentiation of NMDAR-gated currents produced by DYNp. They attenuate DYNp-evoked cell death in spinal cord and prevent, as well as reverse, DYNp-induced paralysis and allodynia. The data reveal a novel mechanism whereby prodynorphin-derived peptides facilitate NMDAR function and produce neurotoxicity. Furthermore, they suggest that synthetic peptides that bind DYNp, thus preventing their interaction with NMDAR, may be novel therapeutic agents for the treatment of spinal cord injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.