ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2006
Homocysteine, folate, lipid profile and MTHFR genotype and disability in children with myelomeningocele.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 7 citations in OpenAlex.
- Fasting serum blood measures of bone and lipid metabolism in children with myelomeningocele for early detection of cardiovascular and bone fragility risk factors.The journal of spinal cord medicine · 2017Article
- A review of the potential for cardiometabolic dysfunction in youth with spina bifida and the role for physical activity and structured exercise.International journal of pediatrics · 2012Article
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6 authors at 1 institution in 1 country.
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Abstract
STUDY
designWe performed a cross-sectional study in myelomeningocele children.
objectiveTo investigate plasma total homocysteine, folate, lipid profile, 5,10- metylenetetrahydrofolate reductase genotype (MTHFR) and disability. MATERIALS AND
methodsSixty patients aged between 2 and 14 years with myelomeningocele (18 ambulatory and 42 non-ambulatory) and 150 healthy children of same age, are investigated for lipid profile, homocysteine concentration and for the determination of MTHFR genotype.
resultsPlasma homocysteine concentrations were significantly higher in myelomeningocele children than in the control group. In myelomeningocele female group, there were higher levels of total cholesterol and very-low-density lipoprotein cholesterol with respect to the control group. Myelomeningocele children walking with tutorial aid showed triglyceride levels significantly lower than those observed in myelomeningocele non-walking children.
conclusionDisability, insulin uptake, lipid, homocysteine, hormones plasma levels, and genetic factors such as allelic variants of MTHFR are possible for cardiovascular disease in myelomeningocele children. This study highlights the importance of a continuous surveillance of any changes in the lipid profile that should be corrected as soon as possible. Constant physical activity necessary to increase HDL levels should be planned in all susceptible children. Nonetheless, further investigations are necessary to identify new homocysteine susceptible genes for prevention of early atherosclerosis and consequent cardiovascular disease.
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