ArticlePsychopharmacology2006
Nitric oxide is involved in the memory facilitation induced by spermidine in rats.
Article in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 41 citations in OpenAlex.
- Trajectories of cardiovascular ageing-from molecular mechanisms to clinical implementation.Cardiovascular research · 2025Review
- Metabolomic study of polyamines in rat urine following intraperitoneal injection of γ-hydroxybutyric acid.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- The use of tucumã oil (Astrocaryum vulgare) in alloxan-induced diabetic mice: effects on behavior, oxidant/antioxidant status, and enzymes involved in brain neurotransmission.Molecular and cellular biochemistry · 2017Article
- Spermidine-induced improvement of reconsolidation of memory involves calcium-dependent protein kinase in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders.Pharmacology & therapeutics · 2015Review
- Effects of chlorogenic acid, caffeine, and coffee on behavioral and biochemical parameters of diabetic rats.Molecular and cellular biochemistry · 2014Article
- Nitric oxide and phytohormone interactions: current status and perspectives.Frontiers in plant science · 2013Review
- Effect of naloxone and morphine on arcaine-induced state-dependent memory in rats.Psychopharmacology · 2011Article
- Arcaine and MK-801 make recall state-dependent in rats.Psychopharmacology · 2008Article
- Anxiolytic effects induced by inhibition of the nitric oxide-cGMP pathway in the rat dorsal hippocampus.Psychopharmacology · 2007Article
- Systemic administration of polyaminergic agents modulate fear conditioning in rats.Psychopharmacology · 2007Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleSpermidine (SPD) is an endogenous polyamine that modulates N-methyl-D: -aspartate receptor functions, which has been reported to facilitate memory formation.
objectivesIn the current study, we investigated the involvement of nitric oxide in the facilitatory effect of SPD on the memory of adult male Wistar rats in the inhibitory avoidance task.
resultsThe coadministration of the nonspecific NOS inhibitor N (G) nitro-L: -arginine methyl ester (L: -NAME) (0.1 nmol, intrahippocampus) with spermidine (0.2 nmol), immediately after training, prevented the memory improvement caused by spermidine in the avoidance inhibitory task. Spermidine increased nitrite and nitrate levels (NO(X)) in the hippocampus 30 min after its administration, and L: -NAME coinjection prevented the stimulatory effect of spermidine on NO(X) levels. The systemic injection of 7-nitroindazole (30 mg/kg, i.p.), 30 min before training, impaired memory and did not prevent spermidine-induced increase of NO(X) levels in the hippocampus.
conclusionsThese results suggest that memory enhancement by spermidine is prevented by the nonspecific nitric oxide synthase inhibitor L: -NAME.
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