ArticleIntensive care medicine2006
Antibacterial-coated tracheal tubes cleaned with the Mucus Shaver : a novel method to retain long-term bactericidal activity of coated tracheal tubes.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01765530 (Endotracheal Tubes Cleaned With a Novel Mechanism for Secretions Removal), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Endotracheal Tubes Cleaned With a Novel Mechanism for Secretions Removal
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Silver-coated endotracheal tubes for prevention of ventilator-associated pneumonia in critically ill patients.The Cochrane database of systematic reviews · 2015Pooled it
- Silver-Coated Endotracheal Tubes Cleaned With a Mechanism for Secretion Removal.Respiratory care · 2019Trial
- A clinical assessment of the Mucus Shaver: a device to keep the endotracheal tube free from secretions.Critical care medicine · 2012Trial
- Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial.Intensive care medicine · 2008Trial
- Biofilm Production in Intensive Care Units: Challenges and Implications.Pathogens (Basel, Switzerland) · 2024Review
- Selected strategies to fight pathogenic bacteria.Journal of enzyme inhibition and medicinal chemistry · 2023Review
- Avoiding ventilator-associated pneumonia: Curcumin-functionalized endotracheal tube and photodynamic action.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Beyond conventional antibiotics - New directions for combination products to combat biofilm.Advanced drug delivery reviews · 2017Review
- Micro-patterned surfaces reduce bacterial colonization and biofilm formation in vitro: Potential for enhancing endotracheal tube designs.Clinical and translational medicine · 2014Article
- From in vitro to in vivo Models of Bacterial Biofilm-Related Infections.Pathogens (Basel, Switzerland) · 2013Review
- Technologic advances in endotracheal tubes for prevention of ventilator-associated pneumonia.Chest · 2012Review
- Reduction of Endotracheal Tube Biofilms Using Antimicrobial Photodynamic Therapy.Lasers in surgery and medicine · 2011Article
- Differences in biofilm formation and antimicrobial resistance of Pseudomonas aeruginosa isolated from airways of mechanically ventilated patients and cystic fibrosis patients.International journal of antimicrobial agents · 2011Article
- Impact of silver-containing wound dressings on bacterial biofilm viability and susceptibility to antibiotics during prolonged treatment.Antimicrobial agents and chemotherapy · 2010Article
- Antimicrobial-coated endotracheal tubes: an experimental study.Intensive care medicine · 2008Article
- Year in review in Intensive Care Medicine, 2006. I. Experimental studies. Clinical studies: brain injury, renal failure and endocrinology.Intensive care medicine · 2007Review
- Comment on "antibacterial-coated tracheal tubes cleaned with a Mucus Shaver" by Berra et al.Intensive care medicine · 2006Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the long-term benefit from antibacterial coatings of the tracheal tube (ETT), and to keep clean the lumen of the ETT.
designExperimental animal study.
settingUSA National Institutes of Health. SUBJECTS: Twelve sheep.
interventionsTwelve ETTs were internally dip-coated with a silver-sulfadiazine in polyurethane. We developed a concentric inflatable silicone rubber "razor", the Mucus Shaver (MS), to shave the ETT lumen free of mucus. In a single pass, we cleaned all mucus from the internal surface of the ETT. CONTROL GROUP: Five intubated sheep were mechanically ventilated for 72 h. The ETT was suctioned every 6 h. STUDY GROUP: Six sheep were intubated and mechanically ventilated for 72 h. The ETT was suctioned and cleaned with the MS every 6 h. An additional sheep was intubated and mechanically ventilated for 168 h. Bacteriologic studies and scanning electron microscopy were performed to assess bacterial colonization and thickness of secretions on the internal surface of the ETT. MEASUREMENTS AND MAIN
resultsIn the control group, the ETT was always heavily colonized: median debris thickness was 380 microm, range 270-550 microm. In the study group, there was no colonization and no secretions in the ETT, except for three ETT that were colonized solely at the very tip.
conclusionsSilver-based coating of ETT cleaned with the MS every 6 h significantly reduces accumulation of mucus/secretion and bacterial growth within the ETT following 72 h of mechanical ventilation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.