ArticleClinical rheumatology2007
Is SAPHO syndrome a target for antibiotic therapy?
Article in Clinical rheumatology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: an interventional study.Arthritis research & therapy · 2009Trial
- Therapeutic approaches for SAPHO syndrome from the perspective of pathogenesis: a review of the literature.Frontiers in immunology · 2025Review
- Abundance alteration of nondominant species in fecal-associated microbiome of patients with SAPHO syndrome.BMC microbiology · 2021Article
- "Autoinflammatory psoriasis"-genetics and biology of pustular psoriasis.Cellular & molecular immunology · 2021Review
- Article
- Neutrophils: Beneficial and Harmful Cells in Septic Arthritis.International journal of molecular sciences · 2018Review
- A case of bronchiolitis obliterans organising pneumonia associated with SAPHO (synovitis-acne-pustulosis-hyperostosis-osteitis) syndrome.BMJ case reports · 2017Article
- SAPHO syndrome: a review.Journal of children's orthopaedics · 2015Article
- The SAPHO syndrome revisited with an emphasis on spinal manifestations.Skeletal radiology · 2015Review
- [SAPHO syndrome].Zeitschrift fur Rheumatologie · 2014Article
- The dark side of SAPHO syndrome.BMJ case reports · 2011Article
- SAPHO Syndrome Diagnosis and Treatment: Report of Five Cases and Review of the Literature.The open orthopaedics journal · 2009Article
- New insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.Current rheumatology reports · 2009Review
- SAPHO syndrome with adrenal deficiency: a case report.Cases journal · 2009Article
- From molecular mimicry to cross-reactivity or pathogen expansion? A hypothesis.Clinical rheumatology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of the synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome remains unclear. Infectious factors are proposed to be relevant in the etiopathogenesis of the disease. To our knowledge, this is the first reported case of a proposed relationship between Staphylococcus aureus cultured from plantar pustule and SAPHO syndrome, which was successfully treated with co-trimoxazole (CTM) (sulfamethoxazole/trimetoprim). CTM might be the drug of choice for therapy for SAPHO syndrome because of combined antibiotic and immunomodulatory properties. Hypersensitivity testing of the medication in vitro was performed to identify, in the preclinical stage, the hypersensitivity reaction to CTM, which may have been severe.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.