ReviewJournal of inherited metabolic disease2006
Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview.
Review in Journal of inherited metabolic disease, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06190314 (SERUM VITAMIN B12 LEVELS IN PATIENTS WITH HEMORRHAGIC VS ISCHEMIC CEREBROVASCULAR EVENT.), which is not on this map. Cited by 119 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Serum vitamin b12 levels in patients with hemorrhagic vs ischemic cerebrovascular event.
Who cites it
119 citing papers in PubMed, 5 syntheses or guidelines pooled it, 319 citations in OpenAlex.
- Pooled it
- Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Alzheimer Disease Risk: a Meta-Analysis.Molecular neurobiology · 2017Pooled it
- The MTHFR C677T Polymorphism and Risk of Intracerebral Hemorrhage in a Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- Increased homocysteine levels in valproate-treated patients with epilepsy: a meta-analysis.BMJ open · 2014Pooled it
- Homocysteine lowering interventions for preventing cardiovascular events.The Cochrane database of systematic reviews · 2009Pooled it
- Riboflavin intake and kidney health: population evidence and mechanistic insights from NHANES and molecular docking analyses.Renal failure · 2026Article
- Ischemic Stroke Increases Protein Expression of the Folate Receptor and One-carbon Enzymes in Brain Tissue From Male and Female Patients.Translational stroke research · 2026Article
- One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation.Biochemistry and biophysics reports · 2026Review
- Epigenetic Modulation of Exercise Adaptation: The Role of Dietary Supplementation in Athletic Performance.Genes · 2026Review
- Ischemic stroke increases levels of the folate receptor and one-carbon enzymes in male and female brain tissue.bioRxiv : the preprint server for biology · 2025Article
- Association between serum homocysteine concentration level and tooth loss: a cross-sectional study from NHANES 2003-2006.Journal of bone and mineral metabolism · 2025Article
- Homocysteine, Nutrition, and Gut Microbiota: A Comprehensive Review of Current Evidence and Insights.Nutrients · 2025Review
- How Increased Dietary Folic Acid Intake Impacts Health Outcomes Through Changes in Inflammation, Angiogenesis, and Neurotoxicity.Nutrients · 2025Review
- The Role of Purinergic Mechanisms in the Excitability of Trigeminal Afferents of Rats with Prenatal Hyperhomocysteinemia.Biomolecules · 2025Article
- Article
- Association of Methylenetetrahydrofolate Reductase rs1801133 Gene Polymorphism with Cancer Risk and Septin 9 Methylation in Patients with Colorectal Cancer.Journal of gastrointestinal cancer · 2024Article
- Evaluating the link between DIO3-FA27 promoter methylation, biochemical indices, and heart failure progression.Clinical epigenetics · 2024Article
- One-carbon metabolite supplementation to nutrient-restricted beef heifers affects placental vascularity during early pregnancy.Journal of animal science · 2024Article
- The Multitarget Action of Vitamins in the Ischemic Stroke.Current topics in medicinal chemistry · 2024Review
- The Implication of a Polymorphism in the Methylenetetrahydrofolate Reductase Gene in Homocysteine Metabolism and Related Civilisation Diseases.International journal of molecular sciences · 2023Review
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for atherosclerosis and vascular disease. Homocysteine is a branch-point intermediate of methionine metabolism, which can be further metabolised via two alternative pathways: degraded irreversibly through the transsulphuration pathway or remethylated to methionine by the remethylation pathway. Both pathways are B-vitamin-dependent. Plasma homocysteine concentrations are determined by nongenetic and genetic factors. The metabolism of homocysteine, the role of B vitamins and the contribution of nongenetic and genetic determinants of homocysteine concentrations are reviewed. The mechanisms whereby homocysteine causes endothelial damage and vascular disease are not fully understood. Recently, a link has been postulated between homocysteine, or its intermediates, and an alterated DNA methylation pattern. The involvement of epigenetic mechanisms in the context of homocysteine and atherosclerosis, due to inhibition of transmethylation reactions, is briefly overviewed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.