ArticleProceedings of the National Academy of Sciences of the United States of America1991
Limited T-cell receptor beta-chain heterogeneity among interleukin 2 receptor-positive synovial T cells suggests a role for superantigen in rheumatoid arthritis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 294 citations in OpenAlex.
- Selective Expansion of TCR Vβ2Experimental dermatology · 2026Article
- Antigen-driven T cell responses in rheumatic diseases: insights from T cell receptor repertoire studies.Nature reviews. Rheumatology · 2025Review
- Endogenous antigens shape the transcriptome and TCR repertoire in an autoimmune arthritis model.The Journal of clinical investigation · 2024Article
- Molecular characterization of enterotoxin genes in methicillin-resistant S. aureus isolated from food poisoning outbreaks in Egypt.Journal of health, population, and nutrition · 2023Article
- Application of T-cell receptor repertoire as a novel monitor in dynamic tracking and assessment: A cohort-study based on RA patients.Journal of cellular and molecular medicine · 2022Article
- Examining pathogenic concepts of autoimmune hepatitis for cues to future investigations and interventions.World journal of gastroenterology · 2019Review
- Microbial Infection and Rheumatoid Arthritis.Journal of clinical & cellular immunology · 2013Article
- An automated point-of-care system for immunodetection of staphylococcal enterotoxin B.Analytical biochemistry · 2011Article
- Electrical percolation-based biosensor for real-time direct detection of staphylococcal enterotoxin B (SEB).Biosensors & bioelectronics · 2010Article
- Nanoliter multiplex PCR arrays on a SlipChip.Analytical chemistry · 2010Article
- Biological semiconductor based on electrical percolation.Analytical chemistry · 2010Article
- Gold nanoparticle-based enhanced chemiluminescence immunosensor for detection of Staphylococcal Enterotoxin B (SEB) in food.International journal of food microbiology · 2009Article
- Association of Mycoplasma arthritidis mitogen with lethal toxicity but not with arthritis in mice.Infection and immunity · 2008Article
- Crystal structures of T cell receptor (beta) chains related to rheumatoid arthritis.Protein science : a publication of the Protein Society · 2005Article
- Simultaneous analysis of multiple staphylococcal enterotoxin genes by an oligonucleotide microarray assay.Journal of clinical microbiology · 2004Article
- A DNA Spiegelmer to staphylococcal enterotoxin B.Nucleic acids research · 2003Article
- Simultaneous analysis of T cell clonality and cytokine production in rheumatoid arthritis using three-colour flow cytometry.Clinical and experimental immunology · 2002Article
- TCR peptide therapy in human autoimmune diseases.Neurochemical research · 2001Review
- CD4+ and CD8+ clonal T cell expansions indicate a role of antigens in ankylosing spondylitis; a study in HLA-B27+ monozygotic twins.Clinical and experimental immunology · 2001Article
- Camel heavy-chain antibodies: diverse germline V(H)H and specific mechanisms enlarge the antigen-binding repertoire.The EMBO journal · 2000Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is a disease affecting the synovial membranes of articulating joints that is thought to result from T-cell-mediated autoimmune phenomena. T cells responsible for the pathogenesis of RA are likely present in that fraction of synovial T cells that expresses the interleukin 2 receptor (IL-2R), one marker of T-cell activation. We report herein an analysis of T-cell receptor (TCR) beta-chain gene expression by IL-2R-positive synovial T cells. These T cells were isolated from uncultured synovial tissue specimens by using IL-2R-specific monoclonal antibodies and magnetic beads, and TCR beta-chain transcription was analyzed by PCR-catalyzed amplification using a panel of primers specific for the human TCR beta-chain variable region (V beta). Multiple V beta gene families were found to be transcribed in these patients samples; however, three gene families, V beta 3, V beta 14, and V beta 17, were found in a majority of the five synovial samples analyzed, suggesting that T cells bearing these V beta s had been selectively retained in the synovial microenvironment. In many instances, the V beta 3, V beta 14, or V beta 17 repertoires amplified from an individual patient were dominated by a single rearrangement, indicative of clonal expansion in the synovium and supportive of a role for these T cells in RA. Of note is a high sequence similarity between V beta 3, V beta 14, and V beta 17 polypeptides, particularly in the fourth complementarity-determining region (CDR). Given that binding sites for superantigens have been mapped to the CDR4s of TCR beta chains, the synovial localization of T cells bearing V beta s with significant CDR4 homology indicates that V beta-specific T-cell activation by superantigen may play a role in RA.
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