ArticleThorax2006
Mast cell migration to Th2 stimulated airway smooth muscle from asthmatics.
Article in Thorax, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Allergen Immunotherapy for the Prevention and Treatment of Asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Review
- An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.Cell · 2019Article
- Article
- Fetal human airway smooth muscle cell production of leukocyte chemoattractants is differentially regulated by fluticasone.Pediatric research · 2015Article
- Human Lung Mast Cell Products Regulate Airway Smooth Muscle CXCL10 Levels.Journal of allergy · 2014Article
- Immunometabolism in obese asthmatics: are we there yet?Nutrients · 2013Review
- Airway smooth muscle in asthma: just a target for bronchodilation?Clinics in chest medicine · 2012Review
- Cross-roads in the lung: immune cells and tissue interactions as determinants of allergic asthma.Immunologic research · 2012Review
- Asthma and COPD - The C/EBP Connection.The open respiratory medicine journal · 2012Article
- The pivotal role of airway smooth muscle in asthma pathophysiology.Journal of allergy · 2011Article
- Chronic inflammation and asthma.Mutation research · 2010Review
- Airway smooth muscle proliferation and survival is not modulated by mast cells.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2010Article
- Interleukin-13: prospects for new treatments.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2010Review
- Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Ion channel regulation of intracellular calcium and airway smooth muscle function.Pulmonary pharmacology & therapeutics · 2009Review
- Actin reorganization is involved in vasoactive intestinal peptide induced human mast cells priming to fraktalkine-induced chemotaxis.International journal of general medicine · 2008Article
- Structural aspects of airway remodeling in asthma.Current allergy and asthma reports · 2008Review
- Article
- Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease.American journal of respiratory cell and molecular biology · 2008Article
- Asthma from a pharmacogenomic point of view.British journal of pharmacology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMast cell microlocalisation within the airway smooth muscle (ASM) bundle is an important determinant of the asthmatic phenotype. We hypothesised that mast cells migrate towards ASM in response to ASM derived chemokines.
methodsPrimary ASM cultures from subjects with and without asthma were stimulated with interleukin (IL)-1beta, IL-4, and IL-13 alone and in combination. Mast cell chemotaxis towards these ASM supernatants was investigated, and the chemotaxins mediating migration by using specific blocking antibodies for stem cell factor (SCF) and the chemokine receptors CCR3, CXCR1, 3 and 4 as well as the Gi inhibitor pertussis toxin and the tyrosine kinase inhibitor genistein were defined. The concentrations of CCL11, CXCL8, CXCL10, TGF-beta, and SCF in the supernatants were measured and the effect of non-asthmatic ASM supernatants on the mast cell chemotactic activity of asthmatic ASM was examined.
resultsHuman lung mast cells and HMC-1 cells migrated towards Th2 stimulated ASM from asthmatics but not non-asthmatics. Mast cell migration was mediated through the combined activation of CCR3 and CXCR1. CCL11 and CXCL8 expression by ASM increased markedly after stimulation, but was similar in those with and without asthma. ASM supernatants from non-asthmatics inhibited mast cell migration towards the asthmatic ASM supernatant.
conclusionTh2 stimulated ASM from asthmatics is chemotactic for mast cells. Non-asthmatic ASM releases a mediator or mediators that inhibit mast cell migration towards stimulated asthmatic ASM. Specifically targeting mast cell migration into the ASM bundle may provide a novel treatment for asthma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.