ArticleGenes & development2006
The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway.
Article in Genes & development, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- The CNK-HYP scaffolding complex promotes RAF activation by enhancing KSR-MEK interaction.Nature structural & molecular biology · 2024Article
- CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling.Nature communications · 2023Article
- Tctp, a unique Ing5-binding partner, inhibits the chromatin binding of Enok inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions.Scientific reports · 2016Article
- Regulatory mechanisms of EGFR signalling during Drosophila eye development.Cellular and molecular life sciences : CMLS · 2016Review
- Drosophila Vps4 promotes Epidermal growth factor receptor signaling independently of its role in receptor degradation.Development (Cambridge, England) · 2015Article
- A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila.PLoS biology · 2014Article
- Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.Development (Cambridge, England) · 2011Article
- Raf family kinases: old dogs have learned new tricks.Genes & cancer · 2011Article
- Mechanistic principles of RAF kinase signaling.Cellular and molecular life sciences : CMLS · 2011Review
- Article
- The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling.Genes & development · 2010Article
- Drosophila Raf's N terminus contains a novel conserved region and can contribute to torso RTK signaling.Genetics · 2010Article
- The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila.Development (Cambridge, England) · 2010Article
- Article
- Myopic acts in the endocytic pathway to enhance signaling by the Drosophila EGF receptor.Development (Cambridge, England) · 2008Article
- CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Review
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Activation of the Raf kinase by GTP-bound Ras is a poorly understood step in receptor tyrosine kinase signaling pathways. One such pathway, the epidermal growth factor receptor (EGFR) pathway, is critical for cell differentiation, survival, and cell cycle regulation in many systems, including the Drosophila eye. We have identified a mutation in a novel gene, aveugle, based on its requirement for normal photoreceptor differentiation. The phenotypes of aveugle mutant cells in the eye and wing imaginal discs resemble those caused by reduction of EGFR pathway function. We show that aveugle is required between ras and raf for EGFR signaling in the eye and for mitogen-activated protein kinase phosphorylation in cell culture. aveugle encodes a small protein with a sterile alpha motif (SAM) domain that can physically interact with the scaffold protein connector enhancer of Ksr (Cnk). We propose that Aveugle acts together with Cnk to promote Raf activation, perhaps by recruiting an activating kinase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.