ArticleProceedings. Biological sciences2006
Quantifying lymphocyte kinetics in vivo using carboxyfluorescein diacetate succinimidyl ester (CFSE).
Article in Proceedings. Biological sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 68 citations in OpenAlex.
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- Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity.Scientific reports · 2014Article
- Modeling T cell responses to antigenic challenge.Journal of pharmacokinetics and pharmacodynamics · 2014Review
- Rates of CTL killing in persistent viral infection in vivo.PLoS computational biology · 2014Article
- Simultaneous analysis of p53 protein expression and cell proliferation in irradiated human lymphocytes by flow cytometry.Dose-response : a publication of International Hormesis Society · 2014Article
- Quantifying T lymphocyte turnover.Journal of theoretical biology · 2013Article
- Evaluation of multitype mathematical models for CFSE-labeling experiment data.Bulletin of mathematical biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cytoplasmic dye carboxyfluorescein diacetate succinimidyl ester (CFSE) is used to quantify cell kinetics. It is particularly important in studies of lymphocyte homeostasis where its labelling of cells irrespective of their stage in the cell cycle makes it preferable to deuterated glucose and BrdU, which only label dividing cells and thus produce unrepresentative results. In the past, experiments have been limited by the need to obtain a clear separation of CFSE peaks forcing scientists to adopt a strategy of in vitro labelling of cells followed by their injection into the host. Here we develop a framework for analysis of in vivo CFSE labelling data. This enables us to estimate the rate of proliferation and death of lymphocytes in situ, and thus represents a considerable advance over current procedures. We illustrate this approach using in vivo CFSE labelling of B lymphocytes in sheep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.