Trial reportBulletin of the World Health Organization1991
Etiology of acute diarrhoea among children in developing countries: a multicentre study in five countries.
Trial report in Bulletin of the World Health Organization, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00368316 (Phase 3 Study), which is not on this map. Cited by 67 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase 3 Study (Safety, Immunogenicity and Efficacy) of Improved Shigella Conjugate Vaccines in 1-4 Year Olds in Israel
Who cites it
67 citing papers in PubMed, 4 syntheses or guidelines pooled it, 223 citations in OpenAlex.
- Systematic review of the rotavirus infection burden in the WHO-EMRO region.Human vaccines & immunotherapeutics · 2019Pooled it
- A systematic review and meta-analysis of the association between Giardia lamblia and endemic pediatric diarrhea in developing countries.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012Pooled it
- Oral vaccines for preventing cholera.The Cochrane database of systematic reviews · 2011Pooled it
- Probiotics for treating acute infectious diarrhoea.The Cochrane database of systematic reviews · 2010Pooled it
- ExploringVaccine: X · 2023Article
- Symptomatic and Asymptomatic Campylobacter Infections and Child Growth in South Asia: Analyzing Data from the Global Enteric Multicenter Study.The American journal of tropical medicine and hygiene · 2023Article
- Etiology of Acute Diarrheal Disease and Antimicrobial Susceptibility Pattern in Children Younger Than 5 Years Old in Nepal.The American journal of tropical medicine and hygiene · 2023Article
- Magnitude, risk factors and antimicrobial susceptibility pattern ofSAGE open medicine · 2021Article
- Article
- Evolution of the World Health Organization's programmatic actions to control diarrheal diseases.Journal of global health · 2019Article
- Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: A case-control study.PLoS neglected tropical diseases · 2019Article
- Article
- Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study.Lancet (London, England) · 2016Article
- Impact of co-infections with enteric pathogens on children suffering from acute diarrhea in southwest China.Infectious diseases of poverty · 2016Article
- Medium- to Long-Term Impact of Rotavirus Vaccination on Hospital Care in Belgium: A 7-Year Follow-Up of the Rotavirus Belgium Impact Study (RotaBIS).Infectious diseases and therapy · 2016Article
- The 12 Gastrointestinal Pathogens Spectrum of Acute Infectious Diarrhea in a Sentinel Hospital, Shenzhen, China.Frontiers in microbiology · 2016Article
- Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED).The Lancet. Global health · 2015Article
- Antibiogram of E. coli serotypes isolated from children aged under five with acute diarrhea in Bahir Dar town.African health sciences · 2015Article
- TleA, a Tsh-like autotransporter identified in a human enterotoxigenic Escherichia coli strain.Infection and immunity · 2015Article
- pEntYN10 a plasmid of Escherichia coli O169:H41 associated with adherence and toxin production.Virulence · 2015Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 2-year etiological survey of acute diarrhoea in children aged 0-35 months who were attending treatment facilities was carried out using a standardized protocol in five hospitals in China, India, Mexico, Myanmar, and Pakistan. A total of 3640 cases of diarrhoea and 3279 age- and sex-matched controls were studied; about 60% of the patients were aged less than 1 year and 60% were male. An enteric pathogen was detected in 68% of the cases and in 30% of the controls. In all the study centres, the pathogens most strongly associated with disease were rotavirus (16% of cases, 2% of controls), Shigella spp. (11% of cases, 1% of controls) and enterotoxigenic Escherichia coli (16% of cases, 5% of controls). Rotavirus was commonest among 6-11-month-olds, accounting for 20% of all cases in this age group; 71% of all rotavirus episodes occurred during the first year of life. Shigella spp. were commonest among those aged 12-23 months and 24-35 months, accounting for 22% and 27% of the cases, respectively. The proportion of cases that yielded no pathogen was inversely related to age, being highest (41%) among infants below 6 months of age and lowest (19%) among those aged 24-35 months. These results suggest that microbe-specific intervention strategies for the control of childhood diarrhoeal diseases in developing countries should focus on rotavirus, Shigella spp. and enterotoxigenic E. coli.
Indexed as
Identifiers
1659953PMC2393250W1622938183What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.