ArticleJournal of clinical immunology2006
Influence of pertussis toxin on CD1a isoform expression in human dendritic cells.
Article in Journal of clinical immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Reinvestigating the Coughing Rat Model of Pertussis To UnderstandInfection and immunity · 2021Article
- Acellular Pertussis Vaccine Components: Today and Tomorrow.Vaccines · 2020Review
- Rediscovering Pertussis.Frontiers in pediatrics · 2016Review
- Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection.Infection and immunity · 2012Article
- Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity.PloS one · 2011Article
- Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes.Clinical & developmental immunology · 2011Review
- Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis.Infection and immunity · 2011Article
- Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools.Future microbiology · 2010Review
- Effect of sialic acid loss on dendritic cell maturation.Immunology · 2009Article
- Pertussis toxin inhibits early chemokine production to delay neutrophil recruitment in response to Bordetella pertussis respiratory tract infection in mice.Infection and immunity · 2008Article
- Sphingosine 1-phosphate as a novel immune regulator of dendritic cells.Journal of biosciences · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pertussis toxin (PTX) is an exotoxin produced by Bordetella pertussis. It is known to exert adjuvant activities inducing Th1-launched immune responses. In this study, we show that PTX can selectively block the expression of CD1a isoform during the differentiation of human monocytes into dendritic cells. In fact, dendritic cells differentiated from monocytes in the presence of PTX do not express CD1a on their surface, unlike CD1b and CD1c isoforms, which are normally regulated. The impaired CD1a expression on cell membrane depends, at least partially, on decreased mRNA transcription and does not affect cellular capability to respond to other maturation stimuli. Since CD1a(+) dendritic cells are involved in the early steps of primary immune response, the interference of PTX in the CD1a expression may be relevant for its employment as adjuvant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.