ArticleClinical research in cardiology : official journal of the German Cardiac Society2006
Increased cardiac mRNA expression of matrix metalloproteinase-1 (MMP-1) and its inhibitor (TIMP-1) in DCM patients.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 29 citations in OpenAlex.
- Beneficial effects of renal sympathetic denervation on cardiovascular inflammation and remodeling in essential hypertension.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Trial
- Prognostic Value of Circulating Fibrosis Biomarkers in Dilated Cardiomyopathy (DCM): Insights into Clinical Outcomes.Biomolecules · 2024Article
- Article
- Changes in Serum Levels of Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinases-1 in Patients with Essential Hypertension.Bioengineering (Basel, Switzerland) · 2022Article
- Inhibitor of lysyl oxidase improves cardiac function and the collagen/MMP profile in response to volume overload.American journal of physiology. Heart and circulatory physiology · 2018Article
- Relationship of polymorphisms in the tissue inhibitor of metalloproteinase (TIMP)-1 and -2 genes with chronic heart failure.Scientific reports · 2018Article
- Associations betweenDisease markers · 2017Article
- Fibrosis of extracellular matrix is related to the duration of the disease but is unrelated to the dynamics of collagen metabolism in dilated cardiomyopathy.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Pathway reporter genes define molecular phenotypes of human cells.BMC genomics · 2015Article
- Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease.Fibrogenesis & tissue repair · 2012Article
- Determinants of extracellular matrix remodelling are differentially expressed in paediatric and adult dilated cardiomyopathy.European journal of heart failure · 2011Article
- Plasma profiling determinants of matrix homeostasis in paediatric dilated cardiomyopathy.Cardiology in the young · 2011Article
- Article
- Prevalence of ventricular discordance and its relation to functional capacity in idiopathic dilated cardiomyopathy.Clinical research in cardiology : official journal of the German Cardiac Society · 2009Article
- Correlations of GDF-15 with sST2, MMPs, and worsening functional capacity in idiopathic dilated cardiomyopathy: Can we gain new insights into the pathophysiology?Journal of circulating biomarkersArticle
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8 authors at 1 institution in 1 country.
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Abstract
Left ventricular dilation and myocardial remodeling are hallmarks of dilated cardiomyopathy (DCM). It is assumed that left ventricular dilation is caused by the disintegration of the collagenous network by increased collagenolytic activity of matrix metalloproteinases (MMPs) and their adequate tissue inhibitors (TIMPs). In this study the myocardial MMP-1 and TIMP-1 mRNA expressions were investigated by using real-time quantitative PCR analysis from right septal endomyocardial biopsies of patients with dilated cardiomyopathy (n = 46) and control subjects (n = 11). The volume density (Vv%) of collagen was measured morphometrically. Classification was done according to LV diameters [left ventricular enddiastolic diameter (LVEDD, cm) calculated to body surface area (BSA, m(2))] into three DCM groups: group I (LVEDD-BSA > 2.7-3.0 cm/m(2)), group II ( > 3.0-3.6 cm/m(2)), group III ( > 3.6 cm/m(2)), controls (< 2.7 cm/m(2)). Compared with controls, the MMP-1 expression in patients with DCM was significantly increased (119.2 +/- 45.2 vs. 1.3 +/- 0.4; p < 0.001) as was TIMP-1 expression (9.6 +/- 1.2 vs. 1.3 +/- 0.4; p < 0.01). Moreover the MMP-1 and TIMP-1 expression varied according to LV diameter: group I (MMP-1: 8.7 +/- 3.5; p = 0.33; TIMP- 1: 4.5 +/- 1.2; p < 0.01); group II (MMP-1: 211.4 +/- 86.0; p < 0.001; TIMP-1: 12.5 +/- 1.9 ; p < 0.001); group III (MMP-1: 38.8 +/- 22.6; p < 0.01; TIMP-1: 8.1 +/- 1.7; p < 0.001). Compared with controls, the collagen level in DCMPt. was significantly increased: 5.0 +/- 0.6 vol% vs 1.2 +/- 0.2 vol% p < 0.001 and correlates with LV diameter. This study reveals that the overexpression of MMP-1, which is associated with an increased ratio of MMP-1/TIMP-1 in DCM, indicates an activated collagenolytic system while replacement fibrosis is accumulating. The MMP-1 overexpression is mainly found in moderately dilated DCM hearts (group II) indicating the dynamic process of LV dilation and the importance of collagenases in the early phase of LV remodeling.
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