ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2006
Childhood fractures are associated with decreased bone mass gain during puberty: an early marker of persistent bone fragility?
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02805647 (Association Between Vitamin D Receptor Polymorphism and Serum Vitamin D Levels in Children With Low-Energy Fractures), which is not on this map. Cited by 52 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Vitamin D Receptor Polymorphism and Serum Vitamin D Levels in Children With Low-Energy Fractures
Who cites it
52 citing papers in PubMed, 166 citations in OpenAlex.
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- Inter-arm bone mass and size asymmetries in children tennis players are maturity status specific: a 9-month study on the effects of training time across pubertal change and somatic growth.European journal of applied physiology · 2024Article
- Familial Resemblance of Bone Health in Maternal Lineage Pairs and Triads: A Scoping Review.Life (Basel, Switzerland) · 2024Article
- Decreased bone mass in adolescents with bone fragility fracture but not in young children: a case-control study.Frontiers in endocrinology · 2023Article
- Is repeated childhood fracture related to areal bone density or body composition in middle age?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
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- The Combined Effects of Milk Intake and Physical Activity on Bone Mineral Density in Korean Adolescents.Nutrients · 2021Article
- Assessing bone mineralisation in children with chronic kidney disease: what clinical and research tools are available?Pediatric nephrology (Berlin, Germany) · 2020Review
- Preschool Obesity Is Associated With an Increased Risk of Childhood Fracture: A Longitudinal Cohort Study of 466,997 Children and Up to 11 Years of Follow-up in Catalonia, Spain.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Management of primary and secondary osteoporosis in children.Therapeutic advances in musculoskeletal disease · 2020Review
- Do teenagers return to normal physical activity levels after limb fractures? A longitudinal, accelerometry-based, activity monitoring study.Journal of children's orthopaedics · 2019Article
- Does peak bone mass correlate with peak bone strength? Cross-sectional normative dual energy X-ray absorptiometry data in 1052 men aged 18-28 years.BMC musculoskeletal disorders · 2019Article
- Circum-menarcheal bone acquisition is stress-driven: A longitudinal study in adolescent female gymnasts and non-gymnasts.Journal of biomechanics · 2018Article
- The association between childhood fractures and adolescence bone outcomes: a population-based study, the Tromsø Study, Fit Futures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Low bone mineral density and fractures are highly prevalent in pediatric patients with spinal muscular atrophy regardless of disease severity.Neuromuscular disorders : NMD · 2017Article
- Prenatal exposure to vitamin D from fortified margarine and risk of fractures in late childhood: period and cohort results from 222 000 subjects in the D-tect observational study.The British journal of nutrition · 2017Observational
- Increasing wrist fracture rates in children may have major implications for future adult fracture burden.Acta orthopaedica · 2016Article
- Life-course approach to nutrition.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Review
- Prior fracture as a risk factor for future fracture in an Australian cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledWhether peak bone mass is low among children with fractures remains uncertain. In a cohort of 125 girls followed over 8.5 years, 42 subjects reported 58 fractures. Among those, BMC gain at multiple sites and vertebral bone size at pubertal maturity were significantly decreased. Hence, childhood fractures may be markers of low peak bone mass acquisition and persistent skeletal fragility.
introductionFractures in childhood may result from a deficit in bone mass accrual during rapid longitudinal growth. Whether low bone mass persists beyond this period however remains unknown. MATERIALS AND
methodsBMC at the spine, radius, hip, and femur diaphysis was prospectively measured over 8.5 years in 125 girls using DXA. Differences in bone mass and size between girls with and without fractures were analyzed using nonparametric tests. The contribution of genetic factors was evaluated by mother-daughter correlations and that of calcium intake by Cox proportional hazard models.
resultsFifty-eight fractures occurred in 42 among 125 girls (cumulative incidence, 46.4%), one-half of all fractures affecting the forearm and wrist. Girls with and without fractures had similar age, height, weight. and calcium intake at all time-points. Before and during early puberty, BMC and width of the radius diaphysis was lower in the fracture compared with no-fracture group (p < 0.05), whereas aBMD and BMAD were similar in the two groups. At pubertal maturity (Tanner's stage 5, mean age +/- SD, 16.4 +/- 0.5 years), BMC at the ultradistal radius (UD Rad.), femur trochanter, and lumbar spine (LS), and LS projected bone area were all significantly lower in girls with fractures. Throughout puberty, BMC gain at these sites was also decreased in the fracture group (LS, -8.0%, p = 0.015; UD Rad., -12.0%, p = 0.004; trochanter, -8.4%, p = 0.05 versus no fractures). BMC was highly correlated between prepuberty and pubertal maturity (R = 0.54-0.81) and between mature daughters and their mothers (R = 0.32-0.46). Calcium intake was not related to fracture risk.
conclusionsGirls with fractures have decreased bone mass gain in the axial and appendicular skeleton and reduced vertebral bone size when reaching pubertal maturity. Taken together with the evidence of tracking and heritability for BMC, these observations indicate that childhood fractures may be markers for low peak bone mass and persistent bone fragility.
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