ArticleNucleic acids research2006
Human centromeric alphoid domains are periodically homogenized so that they vary substantially between homologues. Mechanism and implications for centromere functioning.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Evolution of satDNAs on holocentric chromosomes: insights from hemipteran insects of the genus Mahanarva.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Article
- Centromere defects, chromosome instability, and cGAS-STING activation in systemic sclerosis.Nature communications · 2022Article
- CENP-A: A Histone H3 Variant with Key Roles in Centromere Architecture in Healthy and Diseased States.Results and problems in cell differentiation · 2022Article
- The time is ripe to investigate human centromeres by long-read sequencing†.DNA research : an international journal for rapid publication of reports on genes and genomes · 2021Article
- Rapid and ongoing evolution of repetitive sequence structures in human centromeres.Science advances · 2020Article
- Centromeres under Pressure: Evolutionary Innovation in Conflict with Conserved Function.Genes · 2020Review
- Article
- Interspecies conservation of organisation and function between nonhomologous regional centromeres.Nature communications · 2019Article
- Centromere Repeats: Hidden Gems of the Genome.Genes · 2019Review
- Rapid molecular assays to study human centromere genomics.Genome research · 2017Article
- Diversity and distribution of alpha satellite DNA in the genome of an Old World monkey: Cercopithecus solatus.BMC genomics · 2016Article
- Repression of harmful meiotic recombination in centromeric regions.Seminars in cell & developmental biology · 2016Review
- Completing the human genome: the progress and challenge of satellite DNA assembly.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Molecular sex identification of dry human teeth specimens from Sokoto, Northwestern Nigeria.Journal of forensic dental sciences · 2014Article
- Centromere reference models for human chromosomes X and Y satellite arrays.Genome research · 2014Article
- Article
- Centromere repositioning in mammals.Heredity · 2012Review
- Dynamic distribution patterns of ribosomal DNA and chromosomal evolution in Paphiopedilum, a lady's slipper orchid.BMC plant biology · 2011Article
- Evidence for a high mutation rate at rapidly evolving yeast centromeres.BMC evolutionary biology · 2011Article
- Genome-wide characterization of centromeric satellites from multiple mammalian genomes.Genome research · 2011Article
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sequence analysis of alphoid repeats from human chromosomes 17, 21 and 13 reveals recurrent diagnostic variant nucleotides. Their combinations define haplotypes, with higher order repeats (HORs) containing identical or closely-related haplotypes tandemly arranged into separate domains. The haplotypes found on homologues can be totally different, while HORs remain 99.8% homogeneous both intrachromosomally and between homologues. These results support the hypothesis, never before demonstrated, that unequal crossovers between sister chromatids accumulate to produce homogenization and amplification into tandem alphoid repeats. I propose that the molecular basis of this involves the diagnostic variant nucleotides, which enable pairing between HORs with identical or closely-related haplotypes. Domains are thus periodically renewed to maintain high intrachromosomal and interhomologue homogeneity. The capacity of a domain to form an active centromere is maintained as long as neither retrotransposons nor significant numbers of mutations affect it. In the presented model, a chromosome with an altered centromere can be transiently rescued by forming a neocentromere, until a restored, fully-competent domain is amplified de novo or rehomogenized through the accumulation of unequal crossovers.
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