ArticleNeuro-oncology2006
Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors.
Article in Neuro-oncology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Association between the CYP1B1 polymorphisms and risk of cancer: a meta-analysis.Molecular genetics and genomics : MGG · 2015Pooled it
- Quantitative assessment of the influence of EPHX1 gene polymorphisms and cancer risk: a meta-analysis with 94,213 subjects.Journal of experimental & clinical cancer research : CR · 2014Pooled it
- Cigarette smoking and risk of meningioma: the effect of gender.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Pooled it
- Putative EPHX1 enzyme activity is related with risk of lung and upper aerodigestive tract cancers: a comprehensive meta-analysis.PloS one · 2011Pooled it
- Risk factors associated with vestibulocochlear nerve schwannoma: systematic review.Brazilian journal of otorhinolaryngologyPooled it
- Associations between polymorphisms in DNA repair genes and glioblastoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Trial
- Association between Brain Tumors and Head Injury: A Hospital-Based Case-Control Study in Afghanistan.Asian journal of neurosurgery · 2025Article
- Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth.Acta neuropathologica communications · 2024Article
- GSTM3 Function and Polymorphism in Cancer: Emerging but Promising.Cancer management and research · 2020Review
- Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility.Oncotarget · 2016Article
- Article
- Survival and low-grade glioma: the emergence of genetic information.Neurosurgical focus · 2015Article
- Exogenous hormone use, reproductive factors, and risk of intracranial meningioma in females.Journal of neurosurgery · 2013Article
- The Upper Midwest Health Study: gliomas and occupational exposure to chlorinated solvents.Occupational and environmental medicine · 2013Article
- Investigation of the Association between Genetic Polymorphism of Microsomal Epoxide Hydrolase and Primary Brain Tumor Incidence.Molecular biology international · 2013Article
- Association study of xenobiotic detoxication and repair genes with malignant brain tumors in children.Acta naturae · 2010Article
- Update information on drug metabolism systems--2009, part II: summary of information on the effects of diseases and environmental factors on human cytochrome P450 (CYP) enzymes and transporters.Current drug metabolism · 2010Review
- Molecular epidemiology of primary brain tumors.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
Genes involved in phase I and phase II regulation of aromatic hydrocarbon-induced effects exhibit sequence variability that may mediate the risk of adult brain tumors. We evaluated associations between gene variants in CYP1A1, CYP1B1, GSTM3, EPHX1, and NQO1 and adult brain tumor incidence. Cases were patients with glioma (n = 489), meningioma (n = 197), or acoustic neuroma (n = 96) diagnosed from 1994 to 1998 at three U.S. hospitals. Controls were 799 patients admitted to the same hospitals for nonmalignant conditions. DNA was extracted from blood samples collected from 1277 subjects, and genotyping was conducted for CYP1A1 I462V, CYP1B1 V432L, EPHX1 Y113H, GSTM3 *A/*B (intron 6 deletion), and NQO1 P187S. The CYP1B1 V432L homozygous variant was associated with decreased risk of meningioma (odds ratio [OR] = 0.6; 95% CI, 0.3-1.0) but not the other tumor types. The GSTM3 *B/*B genotype was associated with increased risk of glioma (OR = 2.3; 95% CI, 1.0-5.2) and meningioma (OR = 3.6; 95% CI, 1.3-9.8). Increased risks associated with GSTM3 *B/*B were observed in younger subjects (age < 50) and older subjects (age > or = 50), in men and women, and within each study site. The magnitude of association for GSTM3 with glioma and meningioma was greater among ever-smokers than among those who had never smoked. None of the other genotypes showed consistent associations with any tumor type. The association with the GSTM3 *B allele, while intriguing, requires replication, and additional research is needed to clarify the function of the GSTM3 alleles studied here.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.